Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 3/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 9/20 | 0.60 |
| ▸ | SCD | O00767 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.55 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200871 | 0.87 | CSNK1D (0.77) | WNT3ACSNK1DSCDNFKB1NFKB2 | |
| SCHEMBL4914800 | 0.80 | CSNK1D (0.87) | WNT3ACSNK1DSCDKMT2AMEN1 | |
| SCHEMBL1726569 | 0.78 | WNT3A (1.00) | WNT3ACSNK1DDYRK1A | |
| SCHEMBL17287636 | 0.78 | CSNK1D (0.80) | WNT3ACSNK1DNFKB1NFKB2RELA | |
| SCHEMBL23136935 | 0.78 | CSNK1D (0.78) | WNT3ACSNK1DSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13766283 | 0.77 | CSNK1D (0.70) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 | |
| SCHEMBL13200845 | 0.77 | POLB (0.63) | CSNK1DSCDNFKB1NFKB2RELA | |
| SCHEMBL15112847 | 0.76 | CSNK1D (0.72) | WNT3ACSNK1DSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8665133 | 0.76 | NPC1 (0.51) | WNT3ACSNK1DSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14189668 | 0.76 | CSNK1D (0.77) | CSNK1DNFKB1NFKB2RELASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |