Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.58 |
| ▸ | WNT3A | P56704 | 1/20 | 0.58 |
| ▸ | PLAU | P00749 | 2/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.55 |
| ▸ | PLG | P00747 | 1/20 | 0.55 |
| ▸ | PLAT | P00750 | 1/20 | 0.55 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.55 |
| ▸ | KLK1 | P06870 | 1/20 | 0.55 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14879972 | 0.79 | HDAC8 (0.59) | NAMPTHDAC1CTNNB1WNT3AHDAC2 | |
| SCHEMBL22275525 | 0.78 | CTNNB1 (0.69) | NAMPTCTNNB1WNT3AMEN1KMT2A | |
| SCHEMBL2467402 | 0.77 | PLAU (0.78) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL2273546 | 0.77 | ACLY (0.58) | NAMPTHDAC1CTNNB1WNT3AMEN1 | |
| SCHEMBL573187 | 0.77 | CTNNB1 (0.63) | NAMPTCTNNB1WNT3ANPC1RAB9A | |
| SCHEMBL30489890 | 0.77 | CTNNB1 (0.63) | NAMPTCTNNB1WNT3ANPC1RAB9A | |
| SCHEMBL8383166 | 0.77 | NPC1 (0.56) | NAMPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL14111908 | 0.76 | PLAU (0.76) | PLAUF2PLGPLATKLKB1 | |
| SCHEMBL8292358 | 0.75 | HDAC1 (1.00) | HDAC1PLAUNPC1RAB9AALDH1A1 | |
| SCHEMBL1315526 | 0.74 | PTPN1 (0.87) | HDAC1MEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767670-B2 | Substituted 3-carboxamido isoxazoles as kinase modulators | AMBIT BIOSCIENCES CORPORATION (US) | 2010-08-03 | — | — | US | disclosed |