Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.47 |
| ▸ | RAB9A | P51151 | 10/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.47 |
| ▸ | RELA | Q04206 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | C1R | P00736 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
| ▸ | F3 | P13726 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30059833 | 1.00 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL29541949 | 0.77 | KMO (0.41) | KMT2AMEN1L3MBTL1KDM4EALDH1A1 | |
| SCHEMBL28325888 | 0.76 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31716427 | 0.76 | CASP3 (0.52) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8724386 | 0.76 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL27584137 | 0.76 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4946844 | 0.76 | EPHX2 (0.40) | NPC1RAB9ASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL29825153 | 0.76 | NOTUM (0.51) | KMT2AMEN1L3MBTL1MAPK1NOTUM | |
| SCHEMBL6312443 | 0.73 | ALDH1A1 (0.51) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4478982 | 0.72 | ALDH1A1 (0.47) | NPC1RAB9ASMN1; SMN2KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108348527-A | Method for treating epilepsy | PTC医疗公司 | 2018-07-31 | — | — | CN | claimed |
| CN-105461650-B | Solvate of Yi Zhong oxadiazole compounds and preparation method thereof | 杭州普晒医药科技有限公司 | 2018-04-13 | — | — | CN | claimed |
| CN-108348527-A | Method for treating epilepsy | PTC医疗公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-105461650-B | Solvate of Yi Zhong oxadiazole compounds and preparation method thereof | 杭州普晒医药科技有限公司 | 2018-04-13 | — | — | CN | disclosed |
| US-7772259-B2 | E.g., 3-[5-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid; treating diseases ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay | PTC THERAPEUTICS, INC. (US) | 2010-08-10 | — | — | US | disclosed |