Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.51 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.44 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.44 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636043 | 0.85 | MAPK1 (0.38) | ADORA3SLC29A1TP53TDP1ADK | |
| SCHEMBL7164519 | 0.82 | ADORA3 (0.52) | ADORA3SLC29A1TP53TDP1SIGMAR1 | |
| SCHEMBL7744270 | 0.82 | MAPK1 (0.40) | TP53TDP1HSPA8ADK | |
| SCHEMBL7161653 | 0.81 | TSHR (0.51) | ADORA3SLC29A1TP53TDP1SIGMAR1 | |
| SCHEMBL177666 | 0.81 | HSPA8 (0.44) | ADORA3SLC29A1TP53TDP1SLC28A2 | |
| SCHEMBL2295173 | 0.77 | ADORA2A (0.48) | ADORA3ADORA2AADORA1 | |
| SCHEMBL7744286 | 0.73 | ALDH1A1 (0.39) | SLC29A1TP53TDP1HSPA8ADORA2A | |
| SCHEMBL1170055 | 0.73 | ADORA3 (0.57) | ADORA3METTL3METTL14ADORA2AADORA1 | |
| SCHEMBL1976100 | 0.72 | HSPA8 (0.46) | ADORA3SLC29A1TP53TDP1SLC28A2 | |
| SCHEMBL5177021 | 0.71 | ADORA3 (0.56) | ADORA3TP53HTR2BADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058243-B2 | Method for treating a brain cancer with ifenprodil | HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP (CA) | 2011-11-15 | — | — | US | disclosed |
| US-20090076019-A1 | METHODS FOR TREATING NEUROLOGICAL DISORDERS OR DAMAGE | MOUNT SINAI HOSPITAL (CA) | 2009-03-19 | — | — | US | disclosed |