Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.45 |
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | PPARA | Q07869 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LAP3 | P28838 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ACE | P12821 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655235 | 0.80 | CYP1A2 (0.57) | CYP2D6CYP1A2CYP3A4PRMT1ALDH1A1 | |
| SCHEMBL2668682 | 0.77 | CYP1A2 (0.40) | CYP2D6CYP1A2CYP3A4PRMT1LMNA | |
| SCHEMBL13348421 | 0.69 | CYP2D6 (0.46) | CYP2D6CYP1A2CYP3A4PRMT1LMNA | |
| SCHEMBL10920937 | 0.67 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4PRMT1LMNA | |
| SCHEMBL5680420 | 0.65 | CYP2D6 (0.63) | CYP2D6CYP1A2CYP3A4PRMT1S100A4 | |
| SCHEMBL2668750 | 0.64 | L3MBTL1 (0.37) | CYP1A2S100A4LMNAPPARGPPARA | |
| SCHEMBL1654642 | 0.63 | CYP1A2 (1.00) | CYP2D6CYP1A2CYP3A4PRMT1LMNA | |
| SCHEMBL8463105 | 0.63 | TRPA1 (0.53) | CYP2D6CYP1A2CYP3A4LMNAPPARG | |
| SCHEMBL10136448 | 0.63 | CYP2D6 (0.55) | CYP2D6CYP1A2CYP3A4PRMT1S100A4 | |
| SCHEMBL9800583 | 0.62 | CYP2D6 (0.59) | CYP2D6CYP1A2CYP3A4PRMT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7777047-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-17 | — | — | US | disclosed |
| US-20100144702-A1 | INDOLE COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-10 | — | — | US | disclosed |
| US-20100137610-A1 | Indole compound | YASUMA TSUNEO | 2010-06-03 | — | — | US | disclosed |
| US-7718798-B2 | Indole compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20090286975-A1 | Indole compound | YASUMA TSUNEO | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144702-A1 | INDOLE COMPOUND | GCKR, GPR119, SLC5A1 | CYP2D6 251/4885CYP1A2 404/4885CYP3A4 381/4885 |
| US-20100137610-A1 | Indole compound | GCKR, GPR119, SLC5A1 | CYP2D6 251/4885CYP1A2 404/4885CYP3A4 381/4885 |
| US-20090286975-A1 | Indole compound | GCKR, GPR119, SLC5A1 | CYP2D6 251/4885CYP1A2 404/4885CYP3A4 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.