Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | STAT3 | P40763 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11982989 | 0.82 | GRM1 (0.39) | SMN1; SMN2HTTSTAT3ALDH1A1CYP1A2 | |
| SCHEMBL11983073 | 0.80 | KMT2A (0.42) | SMN1; SMN2HTTSTAT3ALDH1A1HPGD | |
| SCHEMBL22806612 | 0.80 | ALDH1A1 (0.46) | SMN1; SMN2HTTSTAT3ALDH1A1HPGD | |
| SCHEMBL13029622 | 0.79 | ALDH1A1 (0.55) | SMN1; SMN2HTTSTAT3ALDH1A1HPGD | |
| SCHEMBL13344534 | 0.79 | PSMB5 (0.46) | SMN1; SMN2HTTSTAT3ALDH1A1HPGD | |
| SCHEMBL13877542 | 0.79 | STAT3 (0.50) | SMN1; SMN2HTTSTAT3ALDH1A1HPGD | |
| SCHEMBL3207917 | 0.79 | TLR8 (0.57) | ALDH1A1HPGDGAAKDM4EMAPT | |
| SCHEMBL4205004 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2HTTSTAT3ALDH1A1HPGD | |
| SCHEMBL3954275 | 0.79 | KMT2A (0.66) | ALDH1A1HPGDCYP1A2GAAKDM4E | |
| SCHEMBL21195866 | 0.78 | CYP1A2 (0.47) | SMN1; SMN2HTTSTAT3ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841321-B2 | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-23 | — | — | US | disclosed |
| US-8691800-B2 | Quinoline derivatives as antibacterial agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-04-08 | — | — | US | disclosed |
| US-20130030017-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | ANDRIES KOENRAAD JOZEF LODEWIJK MARCEL (BE) | 2013-01-31 | — | — | US | disclosed |
| US-20100204270-A1 | Quinoline Derivatives as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-12 | — | — | US | disclosed |
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-02-25 | — | — | US | disclosed |
| US-20080227775-A1 | Quinoline Derivatives as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-18 | — | — | US | disclosed |
| US-7338949-B2 | Mycobacterial inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-03-04 | — | — | US | disclosed |
| US-20070082895-A1 | Novel mycobacterial inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048585-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | NQO2, HRH1, HRH2 | SMN1; SMN2 4688/4885HTT 1137/4885STAT3 2131/4885 |
| US-20080227775-A1 | Quinoline Derivatives as Antibacterial Agents | NQO2, HRH1, HRH2 | SMN1; SMN2 4749/4885HTT 651/4885STAT3 1626/4885 |
| US-20100204270-A1 | Quinoline Derivatives as Antibacterial Agents | NQO2, NDUFB7, NQO1 | SMN1; SMN2 2822/4885HTT 3818/4885STAT3 1181/4885 |
| US-20130030017-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS | NQO2, NDUFB7, NDUFA7 | SMN1; SMN2 3156/4885HTT 3775/4885STAT3 712/4885 |
| US-20070082895-A1 | Novel mycobacterial inhibitors | HRH4, NAT1, CBR3 | SMN1; SMN2 4693/4885HTT 397/4885STAT3 3621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.