Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.79 |
| ▸ | MEN1 | O00255 | 3/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.79 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9450756 | 0.88 | KDM4E (1.00) | ALDH1A1KDM4EHPGDGAAMAPT | |
| Hydrochloric Acid SCHEMBL11728404 | 0.87 | KDM4E (0.97) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL13431352 | 0.87 | ALDH1A1 (0.77) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL7071108 | 0.84 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL97245 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL7071614 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL7073745 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL7069498 | 0.82 | ALDH1A1 (0.69) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL7071018 | 0.81 | KDM4E (0.85) | ALDH1A1KDM4EHPGDGAAMAPT | |
| SCHEMBL11349500 | 0.80 | KDM4E (0.68) | ALDH1A1KDM4EHPGDGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258293-B2 | Tetrahydroquinoline derivatives | MSD OSS B.V. (NL) | 2012-09-04 | — | — | US | disclosed |
| US-20120202996-A1 | TETRAHYDROQUINOLINE DERIVATIVES | N.V. ORGANON (NL) | 2012-08-09 | — | — | US | disclosed |
| US-8058441-B2 | For control fertility, contraception, breast cancer, prostate cancer and endometriosis; modulating activity of the follicle stimulating hormone (FSH) receptor; 1-Acetyl-6-(tert-butoxycarbonyl)amino-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline | N.V. ORGANON (NL) | 2011-11-15 | — | — | US | disclosed |
| US-20110105477-A1 | COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-05-05 | — | — | US | disclosed |
| CN-1261099-C | Tetrahydroquinoline derivatives | AKZO NOBEL NV (NL) | 2006-06-28 | — | — | CN | disclosed |
| EP-1406628-B1 | TETRAHYDROQUINOLINE DERIVATIVES | AKZO NOBEL NV (NL) | 2006-03-08 | — | — | EP | disclosed |
| US-20040236109-A1 | Tetrahydroquinoline derivatives | MERCK SHARP & DOHME B.V. (NL) | 2004-11-25 | — | — | US | disclosed |
| CN-1529601-A | Tetrahydroquinoline derivatives | ��˹��ŵ�� | 2004-09-15 | — | — | CN | disclosed |
| EP-1406628-A1 | TETRAHYDROQUINOLINE DERIVATIVES | Akzo Nobel N.V. (NL) | 2004-04-14 | — | — | EP | disclosed |
| US-20030176314-A1 | Compounds for the treatment of pain | H. LUNDBECK A/S (DK) | 2003-09-18 | — | — | US | disclosed |
| US-20030139431-A1 | Guanidines which are agonist/antagonist ligands for neuropeptide FF (NPFF) receptors | H. LUNDBECK A/S (DK) | 2003-07-24 | — | — | US | disclosed |
| WO-2003004028-A1 | TETRAHYDROQUINOLINE DERIVATIVES | AKZO NOBEL N.V. (NL) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105477-A1 | COMPOSITIONS AND METHODS RELATING TO HIV PROTEASE INHIBITION | PREP, HPN, PEPD | ALDH1A1 3853/4885KDM4E 1806/4885HPGD 1075/4885 |
| US-20120202996-A1 | TETRAHYDROQUINOLINE DERIVATIVES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ODC1, COX6C | ALDH1A1 2090/4885KDM4E 903/4885HPGD 4121/4885 |
| US-20030176314-A1 | Compounds for the treatment of pain | NPFFR2, NPFFR1, OPRL1 | ALDH1A1 390/4885KDM4E 4560/4885HPGD 537/4885 |
| US-20040236109-A1 | Tetrahydroquinoline derivatives | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, AOC2, HTR3C | ALDH1A1 1145/4885KDM4E 845/4885HPGD 3388/4885 |
| US-20030139431-A1 | Guanidines which are agonist/antagonist ligands for neuropeptide FF (NPFF) receptors | NPFFR1, NPFFR2, SSTR3 | ALDH1A1 3738/4885KDM4E 3447/4885HPGD 3840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.