Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.54 |
| ▸ | F10 | P00742 | 2/20 | 0.54 |
| ▸ | NOS1 | P29475 | 5/20 | 0.50 |
| ▸ | NOS2 | P35228 | 5/20 | 0.50 |
| ▸ | NOS3 | P29474 | 3/20 | 0.50 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20713868 | 0.83 | SMN1; SMN2 (0.57) | F10F2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4253164 | 0.80 | LOXL2 (0.56) | LOXL2F10NOS1NOS2NOS3 | |
| SCHEMBL4253161 | 0.80 | LOXL2 (0.56) | LOXL2F10NOS1NOS2NOS3 | |
| SCHEMBL5154701 | 0.80 | LOXL2 (0.56) | LOXL2F10NOS1NOS2NOS3 | |
| SCHEMBL25447789 | 0.78 | LOXL2 (0.54) | LOXL2F10NOS1NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL6743119 | 0.78 | LOXL2 (0.54) | LOXL2F10NOS1NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL18300737 | 0.78 | LOXL2 (0.54) | LOXL2F10NOS1NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL18300738 | 0.78 | LOXL2 (0.54) | LOXL2F10NOS1NOS2NOS3 | |
| Hydrochloric Acid SCHEMBL6743124 | 0.78 | LOXL2 (0.54) | LOXL2F10NOS1NOS2NOS3 | |
| SCHEMBL23734498 | 0.78 | NOS1 (0.55) | LOXL2F10NOS1NOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7763597-B2 | Salts | ASTRAZENECA AB (SE) | 2010-07-27 | — | — | US | disclosed |
| US-20080269176-A1 | New Salts | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | US | disclosed |
| US-7273858-B2 | Sulfonic acid salts of 2-(p-(alkoxyamidino)benzylaminocarbonyl)azetidin-1-yl 3-chloro-5-(fluorinated alkoxy)-alpha-hydroxybenzyl ketone; competitive inhibitors of trypsin-like proteases, such as thrombin; anticoagulants | ASTRAZENECA AB (SE) | 2007-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269176-A1 | New Salts | PRSS1, PRSS2, CTRL | LOXL2 3656/4885F10 92/4885NOS1 784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.