Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9662341 | 0.98 | ACHE (0.35) | MEN1KMT2AACHEBACE1KCNH2 | |
| SCHEMBL12356587 | 0.69 | TSHR (0.40) | MEN1KMT2AACHEBACE1KCNH2 | |
| Fluoride SCHEMBL29252750 | 0.67 | MEN1 (0.37) | MEN1KMT2AACHEBACE1KCNH2 | |
| SCHEMBL25000897 | 0.64 | DNM1 (0.33) | — | |
| SCHEMBL3659904 | 0.64 | MEN1 (0.38) | MEN1KMT2AACHEBACE1KCNH2 | |
| SCHEMBL20262285 | 0.62 | ESR1 (0.31) | MEN1KMT2AACHEALDH1A1 | |
| SCHEMBL5597049 | 0.62 | TSHR (0.38) | ACHEKCNH2ALDH1A1THRB | |
| SCHEMBL11304936 | 0.62 | TSHR (0.38) | ACHEKCNH2ALDH1A1THRB | |
| SCHEMBL449800 | 0.62 | TSHR (0.38) | ACHEKCNH2ALDH1A1THRB | |
| SCHEMBL168713 | 0.62 | TSHR (0.38) | ACHEKCNH2ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8198823-A | — | — | None | — | — | JP | disclosed |
| EP-2531493-B1 | SUBSTITUTED KETONIC ISOXAZOLINE COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2015-07-22 | — | — | EP | disclosed |
| US-8999889-B2 | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests | BASF SE (DE) | 2015-04-07 | — | — | US | disclosed |
| EP-2531493-A1 | SUBSTITUTED KETONIC ISOXAZOLINE COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2012-12-12 | — | — | EP | disclosed |
| US-20120309620-A1 | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests | BASF SE (DE) | 2012-12-06 | — | — | US | disclosed |
| CN-101016270-B | Substituted piperazinphenylisoxazoline derivative and use thereof | TIANJIN INST PHARM RESEARCH | 2012-05-09 | — | — | CN | disclosed |
| US-8053452-B2 | Substituted isoxazoline or enone oxime compound, and pest control agent | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2011-11-08 | — | — | US | disclosed |
| WO-2011092287-A1 | SUBSTITUTED KETONIC ISOXAZOLINE COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS | BASF SE (DE) | 2011-08-04 | — | — | WO | disclosed |
| CN-101070308-B | Isoxazoline derivative and its use | TIANJIN INST PHARM RESEARCH | 2011-05-04 | — | — | CN | disclosed |
| CN-101220000-B | Acyl chloride and sulfonyl chloride derivant, and uses thereof | TIANJIN INST PHARM RESEARCH | 2010-12-22 | — | — | CN | disclosed |
| US-5686434-A | PHOSPHODIESTERASE TYPE IV INHIBITORS | PFIZER INC. (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0730587-A1 | 3-ARYL-2-ISOXAZOLINES AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0730587-A1 | 3-ARYL-2-ISOXAZOLINES AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| JP-H08198823-A | PRODUCTION OF 3-AMINO-3-ARYL-1-PROPANOL DERIVATIVE | NIPPON SODA CO LTD | 1996-08-06 | — | — | JP | disclosed |
| EP-0719261-A1 | SUBSTITUTED ISOXAZOLINES, PROCESS FOR PRODUCING THEM, AGENTS CONTAINING THEM AND THEIR USE AS SAFENERS | Hoechst Schering AgrEvo GmbH (DE) | 1996-07-03 | — | — | EP | disclosed |
| WO-1995014680-A1 | 3-ARYL-2-ISOXAZOLINES AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| WO-1995014680-A1 | 3-ARYL-2-ISOXAZOLINES AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| WO-1995007897-A1 | SUBSTITUTED ISOXAZOLINES, PROCESS FOR PRODUCING THEM, AGENTS CONTAINING THEM AND THEIR USE AS SAFENERS | HOECHST SCHERING AGREVO GMBH (DE) | 1995-03-23 | — | — | WO | disclosed |
| US-4906277-A | Isoxazoline derivatives and plant growth regulators | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1990-03-06 | — | — | US | disclosed |
| US-4889551-A | Isoxazoline derivatives and plant growth regulators | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1989-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309620-A1 | Substituted ketonic isoxazoline compounds and derivatives for combating animal pests | PDHX, PRDX1, PRDX5 | MEN1 3524/4885KMT2A 489/4885ACHE 290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.