Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MMP13 | P45452 | 7/20 | 0.52 |
| ▸ | MMP2 | P08253 | 6/20 | 0.52 |
| ▸ | MMP8 | P22894 | 6/20 | 0.52 |
| ▸ | MMP9 | P14780 | 5/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244742 | 0.94 | KDM4E (0.59) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL13984525 | 0.91 | KDM4E (0.61) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL13244710 | 0.85 | KDM4E (0.63) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL13267470 | 0.84 | KDM4E (0.62) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL19262713 | 0.79 | DDB1 (0.47) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13267472 | 0.76 | KDM4E (0.65) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL3017442 | 0.75 | KMT2A (0.65) | KDM4ENPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL154383 | 0.75 | DDB1 (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1MMP2 | |
| SCHEMBL255145 | 0.75 | MMP13 (0.57) | ALDH1A1MMP13MMP2MMP8MMP9 | |
| SCHEMBL27805648 | 0.74 | MMP13 (0.56) | MMP13MMP2MMP8MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9617256-B2 | Antibacterial agents | ACHAOGEN, INC. (US) | 2017-04-11 | — | — | US | disclosed |
| EP-2170814-B1 | ANTIBACTERIAL AGENTS | ACHAOGEN INC (US) | 2016-08-17 | — | — | EP | disclosed |
| EP-2662353-A2 | Antibacterial agents | Achaogen, Inc. (US) | 2013-11-13 | — | — | EP | disclosed |
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| WO-2008154642-A2 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | KDM4E 4299/4885NPC1 299/4885RAB9A 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.