Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244710 | 0.92 | KDM4E (0.63) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13984525 | 0.83 | KDM4E (0.61) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13267470 | 0.79 | KDM4E (0.62) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13244708 | 0.76 | KDM4E (0.58) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13244742 | 0.73 | KDM4E (0.59) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13266880 | 0.73 | HRH3 (0.61) | SMN1; SMN2TSHRHRH3 | |
| SCHEMBL7218186 | 0.73 | DRD4 (0.86) | KMT2ASMN1; SMN2DRD2DRD4CYP1A2 | |
| SCHEMBL24728688 | 0.71 | HIF1A (0.68) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL254490 | 0.71 | HRH3 (0.72) | KDM4EKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL3455772 | 0.70 | ALDH1A1 (1.00) | KDM4EKMT2ANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
| WO-2008154642-A2 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | KDM4E 4299/4885KMT2A 4779/4885NPC1 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.