Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 8/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14837450 | 1.00 | TSHR (0.44) | TSHRPOLBALDH1A1GAAHTT | |
| SCHEMBL12227528 | 0.85 | RIPK1 (0.46) | TSHRALDH1A1GAAHTTNPC1 | |
| SCHEMBL14005356 | 0.76 | IDH1 (0.37) | ALDH1A1GAAHTTRIPK1 | |
| SCHEMBL2801378 | 0.74 | ALDH1A1 (0.48) | TSHRPOLBALDH1A1GAAHTT | |
| SCHEMBL7881141 | 0.74 | ALDH1A1 (0.48) | TSHRPOLBALDH1A1GAAHTT | |
| SCHEMBL2801381 | 0.74 | ALDH1A1 (0.48) | TSHRPOLBALDH1A1GAAHTT | |
| SCHEMBL4325826 | 0.70 | NPC1 (0.35) | NPC1LMNATP53HPGDRAB9A | |
| SCHEMBL15743835 | 0.69 | GLS (0.49) | TSHRALDH1A1GAAHTTNPC1 | |
| SCHEMBL19287060 | 0.69 | NR3C2 (0.37) | TSHRPOLBALDH1A1GAAHTT | |
| SCHEMBL15743848 | 0.69 | GLS (0.49) | TSHRALDH1A1GAAHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2161277-B1 | Asymmetric synthesis of peptides | UNIV READING (GB) | 2013-04-10 | — | — | EP | disclosed |
| EP-2161277-B1 | Asymmetric synthesis of peptides | UNIV READING (GB) | 2013-04-10 | — | — | EP | disclosed |
| US-8399612-B2 | Asymmetric synthesis of peptides | UNIVERSITY OF READING (GB) | 2013-03-19 | — | — | US | disclosed |
| US-8399612-B2 | Asymmetric synthesis of peptides | UNIVERSITY OF READING (GB) | 2013-03-19 | — | — | US | disclosed |
| US-20120190816-A9 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING | 2012-07-26 | — | — | US | disclosed |
| US-20120190816-A9 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING | 2012-07-26 | — | — | US | disclosed |
| US-20110275784-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING | 2011-11-10 | — | — | US | disclosed |
| US-20110275784-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING | 2011-11-10 | — | — | US | disclosed |
| US-8044173-B2 | Asymmetric synthesis of peptides | UNIVERSITY OF READING (GB) | 2011-10-25 | — | — | US | disclosed |
| US-8044173-B2 | Asymmetric synthesis of peptides | UNIVERSITY OF READING (GB) | 2011-10-25 | — | — | US | disclosed |
| US-8044173-B2 | Asymmetric synthesis of peptides | UNIVERSITY OF READING (GB) | 2011-10-25 | — | — | US | disclosed |
| EP-2161277-A2 | Asymmetric synthesis of peptides | University of Reading (GB) | 2010-03-10 | — | — | EP | disclosed |
| EP-2161277-A2 | Asymmetric synthesis of peptides | University of Reading (GB) | 2010-03-10 | — | — | EP | disclosed |
| US-20080281075-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING (GB) | 2008-11-13 | — | — | US | disclosed |
| US-20080281075-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING (GB) | 2008-11-13 | — | — | US | disclosed |
| US-20080281075-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING (GB) | 2008-11-13 | — | — | US | disclosed |
| EP-1937708-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | THE UNIVERSITY OF READING (GB) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007031698-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | UNIVERSITY OF READING (GB) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275784-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | PTMS, NGLY1, QPCT | TSHR 492/4885POLB 3177/4885ALDH1A1 4569/4885 |
| US-20080281075-A1 | ASYMMETRIC SYNTHESIS OF PEPTIDES | PTMS, NGLY1, QPCT | TSHR 492/4885POLB 3177/4885ALDH1A1 4569/4885 |
| US-20120190816-A9 | ASYMMETRIC SYNTHESIS OF PEPTIDES | PTMS, NGLY1, QPCT | TSHR 492/4885POLB 3177/4885ALDH1A1 4569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.