Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7881141 | 1.00 | ALDH1A1 (0.48) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL2801381 | 1.00 | ALDH1A1 (0.48) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL3915734 | 0.87 | ALDH1A1 (0.50) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL3915731 | 0.87 | ALDH1A1 (0.50) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL13636872 | 0.85 | ALDH1A1 (0.44) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL11951509 | 0.85 | ALDH1A1 (0.44) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL3925572 | 0.84 | ALDH1A1 (0.51) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL30032505 | 0.84 | ALDH1A1 (0.48) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL3925569 | 0.84 | ALDH1A1 (0.51) | ALDH1A1GAAHTTNPC1LMNA | |
| SCHEMBL6952741 | 0.83 | NPC1 (0.51) | ALDH1A1GAAHTTNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102718770-B | R-homocamptothecin intermediate preparation method | UNIV PLA 2ND MILITARY MEDICAL | 2014-06-04 | — | — | CN | claimed |
| CN-102718770-A | R-homocamptothecin intermediate preparation method | UNIV PLA 2ND MILITARY MEDICAL | 2012-10-10 | — | — | CN | claimed |
| US-11090307-B2 | Treating male senescence | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-08-17 | — | — | US | disclosed |
| CN-107108492-B | Cell necrosis inhibitor | 北京生命科学研究所 | 2021-03-19 | — | — | CN | disclosed |
| US-20200182617-A1 | Necrosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-06-11 | — | — | US | disclosed |
| US-20200046714-A1 | Treating Male Senescence | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-02-13 | — | — | US | disclosed |
| US-10555920-B2 | Necrosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-02-11 | — | — | US | disclosed |
| US-10555920-B2 | Necrosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-02-11 | — | — | US | disclosed |
| US-20190038578-A1 | Necrosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-02-07 | — | — | US | disclosed |
| US-20190038578-A1 | Necrosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-02-07 | — | — | US | disclosed |
| US-10092529-B2 | Necrosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-10-09 | — | — | US | disclosed |
| US-7705155-B2 | Processes for the production of useful intermediates | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) | 2010-04-27 | — | — | US | disclosed |
| US-20090247563-A9 | Novel Processes for the Production of Useful Intermediates | IPSEN/S.C.R.A.S. (ANDRE BOURGOUIN) (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20090247563-A9 | Novel Processes for the Production of Useful Intermediates | IPSEN/S.C.R.A.S. (ANDRE BOURGOUIN) (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20090247563-A9 | Novel Processes for the Production of Useful Intermediates | IPSEN/S.C.R.A.S. (ANDRE BOURGOUIN) (FR) | 2009-10-01 | — | — | US | disclosed |
| US-20070167475-A1 | Novel Processes for the Production of Useful Intermediates | IPSEN/S.C.R.A.S. (ANDRE BOURGOUIN) (FR) | 2007-07-19 | — | — | US | disclosed |
| US-20070167475-A1 | Novel Processes for the Production of Useful Intermediates | IPSEN/S.C.R.A.S. (ANDRE BOURGOUIN) (FR) | 2007-07-19 | — | — | US | disclosed |
| US-20070167475-A1 | Novel Processes for the Production of Useful Intermediates | IPSEN/S.C.R.A.S. (ANDRE BOURGOUIN) (FR) | 2007-07-19 | — | — | US | disclosed |
| EP-1794127-A1 | NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006033011-A1 | NOVEL PROCESSES FOR THE PRODUCTION OF USEFUL INTERMEDIATES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.) (FR) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167475-A1 | Novel Processes for the Production of Useful Intermediates | PGD, TALDO1, COASY | ALDH1A1 449/4885GAA 888/4885HTT 3815/4885 |
| US-11090307-B2 | Treating male senescence | RIPK3, RIPK1, MLKL | ALDH1A1 2786/4885GAA 2827/4885HTT 2157/4885 |
| US-20200046714-A1 | Treating Male Senescence | RIPK3, RIPK1, MLKL | ALDH1A1 2786/4885GAA 2827/4885HTT 2157/4885 |
| US-20090247563-A9 | Novel Processes for the Production of Useful Intermediates | PGD, TALDO1, COASY | ALDH1A1 449/4885GAA 888/4885HTT 3815/4885 |
| US-20190038578-A1 | Necrosis Inhibitors | RIPK3, RIPK1, RIPK4 | ALDH1A1 4104/4885GAA 3062/4885HTT 3280/4885 |
| US-10092529-B2 | Necrosis inhibitors | RIPK3, RIPK1, RIPK4 | ALDH1A1 3900/4885GAA 2668/4885HTT 2632/4885 |
| US-10555920-B2 | Necrosis inhibitors | RIPK3, RIPK1, RIPK4 | ALDH1A1 4104/4885GAA 3062/4885HTT 3280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.