Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24610551 | 0.88 | GABRB2 (0.36) | GABRB2GABRA1POLBCYP2C19GABRA2 | |
| SCHEMBL21513951 | 0.86 | GABRB2 (0.34) | GABRB2GABRA1POLBCYP2C19GABRA2 | |
| SCHEMBL22861003 | 0.81 | CYP2C19 (0.35) | GABRB2GABRA1CYP2C19ACLY | |
| SCHEMBL24610569 | 0.78 | GABRB2 (0.36) | GABRB2GABRA1POLBCYP2C19GABRA2 | |
| SCHEMBL13249069 | 0.78 | ALDH1A1 (0.45) | GABRB2GABRA1POLBCYP2C19ACLY | |
| SCHEMBL668872 | 0.76 | PDE2A (0.41) | GABRB2GABRA1POLBCYP2C19GABRA2 | |
| SCHEMBL1755242 | 0.76 | POLB (0.44) | GABRB2GABRA1POLBCYP2C19GABRA2 | |
| SCHEMBL13166875 | 0.76 | GABRB2 (0.42) | GABRB2GABRA1POLBCYP2C19GABRA2 | |
| SCHEMBL12724897 | 0.75 | GABRB2 (0.37) | GABRB2GABRA1POLBCYP2C19GABRA2 | |
| SCHEMBL24610554 | 0.74 | GABRB2 (0.40) | GABRB2GABRA1POLBCYP2C19GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD (CN) | 2023-04-27 | — | — | US | disclosed |
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | JACOBIO PHARMACEUTICALS CO., LTD (CN) | 2023-04-27 | — | — | US | disclosed |
| US-11384066-B1 | Heterocyclic compounds useful as aurora a selective inhibitors | JACOBIO PHARMACEUTICALS CO., LTD. (CN) | 2022-07-12 | — | — | US | disclosed |
| US-9095138-B2 | Isoxazoline insecticides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2015-08-04 | — | — | US | disclosed |
| US-20150098928-A9 | ISOXAZOLINE INSECTICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2015-04-09 | — | — | US | disclosed |
| US-20140127165-A1 | ISOXAZOLINE INSECTICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-05-08 | — | — | US | disclosed |
| US-8623875-B2 | Isoxazoline insecticides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-01-07 | — | — | US | disclosed |
| US-20100179195-A1 | ISOXAZOLINE INSECTICIDES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2010-07-15 | — | — | US | disclosed |
| US-20100179195-A1 | ISOXAZOLINE INSECTICIDES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11384066-B1 | Heterocyclic compounds useful as aurora a selective inhibitors | AURKA, AURKC, AURKB | GABRB2 4639/4885GABRA1 4504/4885POLB 1600/4885 |
| US-20230128198-A1 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL AS AURORA A SELECTIVE INHIBITORS | AURKA, AURKC, AURKB | GABRB2 4674/4885GABRA1 4455/4885POLB 2327/4885 |
| US-20150098928-A9 | ISOXAZOLINE INSECTICIDES | CBR3, CYP4X1, PRDX1 | GABRB2 1307/4885GABRA1 903/4885POLB 4204/4885 |
| US-20140127165-A1 | ISOXAZOLINE INSECTICIDES | CBR3, CYP4X1, PRDX1 | GABRB2 1307/4885GABRA1 903/4885POLB 4204/4885 |
| US-20100179195-A1 | ISOXAZOLINE INSECTICIDES | CBR3, CYP4X1, PRDX1 | GABRB2 1307/4885GABRA1 903/4885POLB 4204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.