Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRLHR | P49683 | 15/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13250009 | 0.97 | MGLL (0.37) | PRLHRMGLLTRPV1 | |
| SCHEMBL13250012 | 0.91 | MGLL (0.41) | MGLLTRPV1 | |
| SCHEMBL13249804 | 0.91 | MGLL (0.41) | PRLHRMGLLTRPV1 | |
| SCHEMBL13249814 | 0.91 | MGLL (0.41) | MGLLTRPV1 | |
| SCHEMBL13250094 | 0.88 | MGLL (0.39) | MGLLTRPV1 | |
| SCHEMBL13249994 | 0.86 | LIPE (0.40) | PRLHRTRPV1 | |
| SCHEMBL13250001 | 0.85 | MGLL (0.37) | MGLLTRPV1 | |
| SCHEMBL13250020 | 0.84 | KCNH2 (0.38) | TRPV1 | |
| SCHEMBL13249795 | 0.84 | MGLL (0.47) | MGLLTRPV1 | |
| SCHEMBL13328962 | 0.84 | MGLL (0.41) | PRLHRMGLLTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190687-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-07-29 | — | — | US | disclosed |
| US-20100190687-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190687-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, GCGR, GPR65 | PRLHR 263/4885MGLL 882/4885TRPV1 632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.