Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13257642 | 0.86 | PDE7A (0.51) | LMNAALDH1A1CYP2C9CYP2C19MAPK1 | |
| SCHEMBL13258438 | 0.84 | LMNA (0.40) | LMNAPOLBALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL13257534 | 0.84 | APLNR (0.49) | LMNACYP2C19MAPK1PDE7A | |
| SCHEMBL13257672 | 0.83 | LMNA (0.39) | LMNAPOLBALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL13257463 | 0.82 | ALDH1A1 (0.35) | LMNAPOLBALDH1A1SMN1; SMN2ESR1 | |
| SCHEMBL2570522 | 0.82 | POLB (0.48) | LMNAPOLBALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL13257678 | 0.82 | PDE11A (0.43) | LMNACYP2C19ESR1KDM4EESR2 | |
| SCHEMBL13266361 | 0.81 | LMNA (0.38) | LMNAPOLBALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL13258437 | 0.80 | PDE7A (0.40) | LMNAALDH1A1PDE7APDE7B | |
| SCHEMBL13266358 | 0.80 | LMNA (0.45) | LMNAPOLBALDH1A1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010087467-A1 | DELTA-5-DESATURASE INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-05 | — | — | WO | disclosed |