Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10132490 | 0.81 | HTR6 (0.46) | POLBHTR6CHRNA3 | |
| SCHEMBL19590964 | 0.73 | CHRNB2 (0.40) | POLBHTR6CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL9520411 | 0.72 | POLB (0.49) | POLBHTR6HSD17B10CHRNB4CHRNA3 | |
| SCHEMBL10132336 | 0.71 | POLB (0.61) | POLBHTR6CHRNB2CHRNA4 | |
| SCHEMBL19654759 | 0.71 | POLB (0.61) | POLBHTR6CHRNB2CHRNA4 | |
| SCHEMBL31189119 | 0.70 | POLB (0.50) | POLBHTR6CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL1485223 | 0.69 | HTR6 (0.55) | POLBHTR6CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL20109493 | 0.69 | HTR6 (0.55) | POLBHTR6CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL10272588 | 0.68 | POLB (0.61) | POLBHTR6CHRNB4CHRNA3 | |
| SCHEMBL168722 | 0.68 | CHRM2 (0.46) | MEN1KMT2AHSD17B10CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010074088-A1 | CYCLIC AMINE COMPOUNDS | 第一三共株式会社 (JP) | 2010-07-01 | — | — | WO | disclosed |