Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13244724 | 0.92 | MMP13 (0.48) | NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL13984818 | 0.84 | HIF1A (0.57) | NPC1RAB9ASMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL13267167 | 0.84 | HIF1A (0.57) | NPC1RAB9ASMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL13267483 | 0.83 | NPC1 (0.47) | NPC1RAB9AHIF1AEPAS1HDAC1 | |
| SCHEMBL203863 | 0.79 | ANPEP (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1109236 | 0.78 | HDAC1 (0.53) | NPC1RAB9ASMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL13267039 | 0.77 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL14400854 | 0.77 | KMT2A (0.51) | NPC1HIF1AEPAS1HDAC1KMT2A | |
| SCHEMBL13984670 | 0.77 | KDM4E (0.55) | NPC1RAB9ASMN1; SMN2HIF1AEPAS1 | |
| SCHEMBL9925870 | 0.77 | KMT2A (0.51) | NPC1HIF1AEPAS1HDAC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190766-A1 | ANTIBACTERIAL AGENTS | MRPL21, SI, ABCB11 | NPC1 299/4885RAB9A 509/4885SMN1; SMN2 2202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.