Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 6/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.46 |
| ▸ | KRAS | P01116 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | ARG1 | P05089 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12124766 | 1.00 | DPP4 (0.54) | DPP4KDM4EMEN1LMNAMPO | |
| SCHEMBL12124742 | 0.85 | ALDH1A1 (0.48) | KDM4EMEN1LMNAMAPTKMT2A | |
| SCHEMBL13284351 | 0.84 | ALDH1A1 (0.37) | DPP4KDM4EMEN1LMNAMAPT | |
| SCHEMBL1327525 | 0.84 | GHSR (0.39) | DPP4MEN1KMT2AHDAC8TACR1 | |
| SCHEMBL1327521 | 0.84 | GHSR (0.39) | DPP4MEN1KMT2AHDAC8TACR1 | |
| SCHEMBL1327522 | 0.84 | GHSR (0.39) | DPP4MEN1KMT2AHDAC8TACR1 | |
| SCHEMBL1328279 | 0.82 | GLA (0.52) | KDM4EMEN1LMNAMAPTKMT2A | |
| SCHEMBL29802831 | 0.82 | GLA (0.52) | KDM4EMEN1LMNAMAPTKMT2A | |
| SCHEMBL1327610 | 0.82 | GLA (0.52) | KDM4EMEN1LMNAMAPTKMT2A | |
| SCHEMBL1326705 | 0.82 | GLA (0.52) | KDM4EMEN1LMNAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389383-B1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RES (IL) | 2019-04-24 | — | — | EP | disclosed |
| US-9034891-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2015-05-19 | — | — | US | disclosed |
| US-8673931-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2014-03-18 | — | — | US | disclosed |
| US-20130225624-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2013-08-29 | — | — | US | disclosed |
| EP-2389383-A2 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2011-11-30 | — | — | EP | disclosed |
| US-20110281903-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2011-11-17 | — | — | US | disclosed |
| US-8038638-B2 | Plasma detoxification and volume control system and methods of use | HEMOLIFE MEDICAL, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| WO-2010084499-A9 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010084499-A2 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225624-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | CHRM3, CHRM1, CHRM2 | DPP4 2891/4885KDM4E 3870/4885MEN1 1829/4885 |
| US-20110281903-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | GPR119, CHRM2, CHRM1 | DPP4 1125/4885KDM4E 3553/4885MEN1 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.