Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MC5R | P33032 | 1/20 | 0.45 |
| ▸ | MC3R | P41968 | 1/20 | 0.45 |
| ▸ | MC1R | Q01726 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1326705 | 1.00 | GLA (0.52) | GLAKMT2ALMNAALDH1A1GAA | |
| SCHEMBL29802831 | 1.00 | GLA (0.52) | GLAKMT2ALMNAALDH1A1GAA | |
| SCHEMBL1327610 | 1.00 | GLA (0.52) | GLAKMT2ALMNAALDH1A1GAA | |
| SCHEMBL1327542 | 0.94 | ALDH1A1 (0.53) | GLAKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL12124742 | 0.91 | ALDH1A1 (0.48) | GLAKMT2ALMNAALDH1A1MEN1 | |
| SCHEMBL20922823 | 0.89 | HTR6 (0.42) | GLAKMT2AALDH1A1GAAMAPT | |
| SCHEMBL12124766 | 0.82 | DPP4 (0.54) | KMT2ALMNAMEN1MAPTKDM4E | |
| SCHEMBL1327448 | 0.82 | DPP4 (0.54) | KMT2ALMNAMEN1MAPTKDM4E | |
| SCHEMBL20922555 | 0.82 | GLA (0.53) | GLAKMT2ALMNAALDH1A1GAA | |
| SCHEMBL1327787 | 0.82 | HSD17B10 (0.52) | KMT2ALMNAALDH1A1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2389383-B1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RES (IL) | 2019-04-24 | — | — | EP | claimed |
| US-8673931-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2014-03-18 | — | — | US | claimed |
| US-20130225624-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2013-08-29 | — | — | US | claimed |
| EP-2389383-B1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RES (IL) | 2019-04-24 | — | — | EP | disclosed |
| EP-2389383-B1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RES (IL) | 2019-04-24 | — | — | EP | disclosed |
| US-9034891-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2015-05-19 | — | — | US | disclosed |
| US-9034891-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2015-05-19 | — | — | US | disclosed |
| US-9034891-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2015-05-19 | — | — | US | disclosed |
| US-8673931-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2014-03-18 | — | — | US | disclosed |
| US-8673931-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2014-03-18 | — | — | US | disclosed |
| US-8673931-B2 | Bicyclic heterocyclic spiro compounds | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2014-03-18 | — | — | US | disclosed |
| US-20130225624-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2013-08-29 | — | — | US | disclosed |
| US-20130225624-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2013-08-29 | — | — | US | disclosed |
| US-20130225624-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2013-08-29 | — | — | US | disclosed |
| US-20110281903-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2011-11-17 | — | — | US | disclosed |
| US-20110281903-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2011-11-17 | — | — | US | disclosed |
| US-20110281903-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2011-11-17 | — | — | US | disclosed |
| WO-2010084499-A9 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010084499-A2 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH (IL) | 2010-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225624-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | CHRM3, CHRM1, CHRM2 | GLA 2824/4885KMT2A 3332/4885LMNA 2767/4885 |
| US-20110281903-A1 | BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS | GPR119, CHRM2, CHRM1 | GLA 1264/4885KMT2A 2655/4885LMNA 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.