Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327170 | 0.85 | RAB9A (0.49) | MEN1KMT2AHPGDOPRL1NPC1 | |
| SCHEMBL2310340 | 0.85 | OPRL1 (0.40) | MEN1KMT2AOPRM1OPRL1 | |
| SCHEMBL493392 | 0.83 | OPRL1 (0.44) | OPRM1OPRL1 | |
| SCHEMBL1326706 | 0.82 | HTR7 (0.42) | MEN1KMT2AOPRM1HTR7OPRL1 | |
| SCHEMBL2310616 | 0.82 | CACNA1I (0.48) | OPRM1HTR7OPRL1 | |
| SCHEMBL492704 | 0.81 | OPRL1 (0.44) | OPRM1OPRL1 | |
| SCHEMBL493393 | 0.81 | OPRL1 (0.44) | OPRM1OPRL1 | |
| SCHEMBL1327345 | 0.81 | OPRL1 (0.41) | OPRM1OPRL1NPC1RAB9AKDM4E | |
| SCHEMBL1328275 | 0.81 | DRD2 (0.42) | OPRL1 | |
| SCHEMBL28774679 | 0.81 | NPC1 (0.48) | KMT2AOPRL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8058475-B2 | Substituted cyclohexylmethyl compounds | GRUENENTHAL GMBH (DE) | 2011-11-15 | — | — | US | claimed |
| EP-1989174-B1 | SUBSTITUTED CYCLOHEXYLMETHYL DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-08-03 | — | — | EP | claimed |
| US-8058475-B2 | Substituted cyclohexylmethyl compounds | GRUENENTHAL GMBH (DE) | 2011-11-15 | — | — | US | disclosed |