Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL492705 | 0.93 | OPRL1 (0.44) | OPRL1OPRM1PTGIROPRD1OPRK1 | |
| SCHEMBL492704 | 0.92 | OPRL1 (0.44) | OPRL1OPRM1PTGIROPRD1OPRK1 | |
| SCHEMBL1327796 | 0.88 | OPRL1 (0.43) | OPRL1OPRM1PTGIROPRD1OPRK1 | |
| SCHEMBL493392 | 0.87 | OPRL1 (0.44) | OPRL1OPRM1PTGIROPRD1OPRK1 | |
| SCHEMBL2307382 | 0.87 | CNR2 (0.50) | OPRL1OPRM1PTGIROPRD1 | |
| SCHEMBL1327170 | 0.83 | RAB9A (0.49) | OPRL1 | |
| SCHEMBL1326793 | 0.83 | OPRL1 (0.45) | OPRL1OPRM1PTGIROPRD1OPRK1 | |
| SCHEMBL1326706 | 0.82 | HTR7 (0.42) | OPRL1OPRM1PTGIR | |
| SCHEMBL2310616 | 0.82 | CACNA1I (0.48) | OPRL1OPRM1 | |
| SCHEMBL493073 | 0.81 | AOC3 (0.41) | OPRL1OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | OPRL1 4/4885HTR6 2114/4885OPRM1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.