Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.72 |
| ▸ | CCNC | P24863 | 1/20 | 0.72 |
| ▸ | CDK8 | P49336 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 8/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | LDHA | P00338 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 9/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.64 |
| ▸ | USP2 | O75604 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14300930 | 0.92 | LMNA (0.76) | HTTCCNCCDK8LMNAMAPT | |
| SCHEMBL13283184 | 0.86 | LMNA (0.85) | HTTCCNCCDK8LMNALDHA | |
| SCHEMBL14300974 | 0.85 | HTT (0.75) | HTTCCNCCDK8LMNAMAPT | |
| SCHEMBL6672212 | 0.84 | ALDH1A1 (0.76) | HTTLMNAMAPTLDHAALDH1A1 | |
| SCHEMBL4359487 | 0.84 | HTT (1.00) | HTTCCNCCDK8LMNAMAPT | |
| SCHEMBL13283187 | 0.82 | LMNA (0.75) | HTTCCNCCDK8LMNAMAPT | |
| SCHEMBL4359385 | 0.81 | HTT (0.83) | HTTCCNCCDK8LMNAMAPT | |
| SCHEMBL11246544 | 0.81 | LDHA (1.00) | HTTLMNAMAPTLDHAALDH1A1 | |
| SCHEMBL13874409 | 0.81 | HTT (0.73) | HTTCCNCCDK8LMNAMAPT | |
| SCHEMBL5076850 | 0.81 | LMNA (1.00) | HTTCCNCCDK8LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190807-A1 | CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein | SENEX BIOTECHNOLOGY, INC. | 2010-07-29 | — | — | US | disclosed |
| US-20090281129-A1 | CDKI PATHWAY INHIBITORS AND USES THEREOF | SENEX BIOTECHNOLOGY, INC. | 2009-11-12 | — | — | US | disclosed |
| US-20080033000-A1 | Identification of CDKI pathway inhibitors | SENEX BIOTECHNOLOGY, INC. | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190807-A1 | CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein | MAPT, CDK5, CDKN1A | HTT 292/4885CCNC 89/4885CDK8 13/4885 |
| US-20090281129-A1 | CDKI PATHWAY INHIBITORS AND USES THEREOF | CDKN1A, CDK6, CCNI | HTT 930/4885CCNC 32/4885CDK8 9/4885 |
| US-20080033000-A1 | Identification of CDKI pathway inhibitors | CDKN1A, CDK6, CDK2 | HTT 1550/4885CCNC 36/4885CDK8 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.