Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 10/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31511298 | 0.87 | PNMT (0.45) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL17018035 | 0.87 | PNMT (0.45) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL16585592 | 0.87 | PNMT (0.45) | PNMTADRA2AADRA2BADRA2CHTR2A | |
| SCHEMBL24359176 | 0.79 | HTR5A (0.39) | HTR2AHTR2CHTR2BAR | |
| SCHEMBL10991106 | 0.79 | HTR5A (0.39) | HTR2AHTR2CHTR2BAR | |
| SCHEMBL3726820 | 0.78 | ESR2 (0.46) | — | |
| SCHEMBL4102066 | 0.78 | HTR2C (0.44) | HTR2AHTR2CHTR2BAR | |
| SCHEMBL3118450 | 0.78 | KDM4E (0.47) | HTR2AARLMNA | |
| SCHEMBL4130897 | 0.75 | MTNR1A (0.45) | — | |
| SCHEMBL424121 | 0.75 | MTNR1A (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010080478-A1 | COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-07-15 | — | — | WO | disclosed |