Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 16/20 | 0.70 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13284394 | 0.73 | DRD4 (0.50) | DRD4HTR1AHTR1DHTR1B | |
| SCHEMBL22619011 | 0.72 | DRD2 (0.53) | DRD4SIGMAR1DRD2DRD3HTR1A | |
| SCHEMBL352001 | 0.71 | DRD4 (0.71) | DRD4DRD2DRD3 | |
| SCHEMBL1877824 | 0.71 | DRD4 (0.71) | DRD4DRD2DRD3 | |
| SCHEMBL5695486 | 0.71 | DRD4 (0.71) | DRD4DRD2DRD3 | |
| SCHEMBL27249809 | 0.69 | DRD4 (0.42) | DRD4DRD2DRD3 | |
| SCHEMBL27249808 | 0.69 | DRD4 (0.42) | DRD4DRD2DRD3 | |
| SCHEMBL28256636 | 0.69 | L3MBTL1 (0.56) | DRD4DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL28791958 | 0.67 | DRD4 (0.45) | DRD4HTR1AHTR1DHTR1B | |
| SCHEMBL22121721 | 0.66 | DRD4 (0.52) | DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077976-A2 | PROKINETICIN RECEPTOR ANTAGONISTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-08 | — | — | WO | disclosed |