Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | TPO | P07202 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CFB | P00751 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28791958 | 0.85 | DRD4 (0.45) | DRD4HTR1AHTR1DHTR1BALDH1A1 | |
| SCHEMBL23932511 | 0.79 | HTR1A (0.47) | DRD4HTR1AHTR1DHTR1BALDH1A1 | |
| SCHEMBL13356639 | 0.74 | DRD4 (0.41) | DRD4HTR1AHTR1DHTR1BMPO | |
| SCHEMBL13284775 | 0.73 | DRD4 (0.70) | DRD4HTR1AHTR1DHTR1B | |
| SCHEMBL13284389 | 0.72 | KDM4E (0.65) | DRD4ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL3921135 | 0.72 | ACHE (0.68) | DRD4ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL22619011 | 0.72 | DRD2 (0.53) | DRD4HTR1A | |
| SCHEMBL11196594 | 0.71 | ALDH1A1 (0.69) | ALDH1A1KDM4EPOLBMPOLMNA | |
| SCHEMBL5243691 | 0.71 | HTR1A (0.53) | DRD4HTR1AHTR1DHTR1BKDM4E | |
| SCHEMBL2399846 | 0.71 | AHR (0.50) | AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010077976-A2 | PROKINETICIN RECEPTOR ANTAGONISTS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-07-08 | — | — | WO | disclosed |