Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 8/20 | 0.74 |
| ▸ | CREB1 | P16220 | 6/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.74 |
| ▸ | MAPT | P10636 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | TP53 | P04637 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.74 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.74 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.74 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.74 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | GABRP | O00591 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17265620 | 0.90 | ABCB1 (0.80) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL16521506 | 0.88 | ADORA3 (0.69) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL16521508 | 0.86 | ABCB1 (0.55) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| Baicalein SCHEMBL28365951 | 0.85 | ABCB1 (0.94) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL12978376 | 0.85 | CREB1 (0.79) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| Baicalein SCHEMBL5695785 | 0.85 | ABCB1 (1.00) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| Baicalein SCHEMBL29385549 | 0.85 | ABCB1 (1.00) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| Baicalein SCHEMBL139617 | 0.85 | ABCB1 (1.00) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| SCHEMBL6245328 | 0.84 | ABCB1 (1.00) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 | |
| Baicalein SCHEMBL28630648 | 0.84 | ABCB1 (0.97) | ABCB1CREB1CYP3A4MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9415034-B2 | Inhibitors and enhancers of uridine diphosphate-glucuronosyltransferase 2B (UGT2B) | NATIONAL DEFENSE MEDICAL CENTER (TW) | 2016-08-16 | — | — | US | disclosed |
| US-20160184298-A1 | INHIBITORS AND ENHANCERS OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE 2B (UGT2B) | NAT DEFENSE MEDICAL CT (TW) | 2016-06-30 | — | — | US | disclosed |
| US-9120744-B2 | Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-09-01 | — | — | US | disclosed |
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2010-06-03 | — | — | US | disclosed |
| US-20090074708-A1 | Inhibitors and Enhancers of Uridine Diphosphate-Glucuronosyltransferase 2B (UGT2B) | NATIONAL DEFENSE MEDICAL UNIVERSITY (TW) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137194-A1 | Plasminogen Activator Inhibitor-1 Inhibitors and Methods of Use Thereof to Modulate Lipid Metabolism | SERPINE1, PLAT, SERPINB1 | ABCB1 2208/4885CREB1 1877/4885CYP3A4 1379/4885 |
| US-20160184298-A1 | INHIBITORS AND ENHANCERS OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE 2B (UGT2B) | UGT2B7, UGT2B17, UGT1A10 | ABCB1 18/4885CREB1 4560/4885CYP3A4 23/4885 |
| US-20090074708-A1 | Inhibitors and Enhancers of Uridine Diphosphate-Glucuronosyltransferase 2B (UGT2B) | UGT2B7, UGT2B17, UGT1A10 | ABCB1 18/4885CREB1 4560/4885CYP3A4 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.