Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13120220 | 0.89 | GSK3B (0.61) | GSK3BCDK2 | |
| SCHEMBL13289269 | 0.86 | GSK3B (0.46) | GSK3BCDK2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL13288875 | 0.86 | GSK3B (0.46) | GSK3BCDK2ABL1ALDH1A1CYP1A2 | |
| SCHEMBL14545893 | 0.85 | CDK2 (0.46) | GSK3BCDK2ALDH1A1POLBLMNA | |
| SCHEMBL13288970 | 0.85 | CDK2 (0.45) | GSK3BCDK2ABL1 | |
| SCHEMBL14545258 | 0.85 | GSK3B (0.46) | GSK3BCDK2ALDH1A1TP53 | |
| SCHEMBL13288908 | 0.85 | GSK3B (0.42) | GSK3BCDK2ABL1ALDH1A1TP53 | |
| SCHEMBL13288732 | 0.84 | CDK2 (0.43) | GSK3BCDK2ALDH1A1TP53POLB | |
| SCHEMBL14545832 | 0.84 | CDK2 (0.48) | GSK3BCDK2ALDH1A1TP53LMNA | |
| SCHEMBL13120009 | 0.84 | GSK3B (0.59) | GSK3BCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |