Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.74 |
| ▸ | CES1 | P23141 | 3/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.53 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.53 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8182343 | 0.88 | CES2 (0.59) | CES2CES1MAPK14MAPK13MAPK12 | |
| SCHEMBL29880739 | 0.87 | CES2 (0.63) | CES2CES1MAPK14MAPK13MAPK12 | |
| SCHEMBL8609990 | 0.87 | CES2 (0.63) | CES2CES1MAPK14MAPK13MAPK12 | |
| SCHEMBL8070666 | 0.85 | CES2 (1.00) | CES2CES1L3MBTL1SNCANPC1 | |
| SCHEMBL8864704 | 0.84 | ALDH1A1 (0.55) | CES2CES1MAPK14MAPK13MAPK12 | |
| SCHEMBL158348 | 0.83 | CES2 (0.59) | CES2CES1MAPK14KMT2AL3MBTL1 | |
| SCHEMBL29765677 | 0.83 | CES2 (0.59) | CES2CES1MAPK14KMT2AL3MBTL1 | |
| SCHEMBL14431511 | 0.83 | CES2 (0.59) | CES2CES1MAPK14HTTKMT2A | |
| SCHEMBL8176735 | 0.83 | ALB (0.55) | CES2CES1MAPK14MAPK13MAPK12 | |
| SCHEMBL19519478 | 0.83 | CES2 (0.53) | CES2CES1MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104370909-B | Tricyclic compound | ABBVIE 公司 | 2018-09-11 | — | — | CN | claimed |
| CN-109400610-A | Pyrrolo-triazine analog derivative, preparation method and its purposes in medicine | 浙江海正药业股份有限公司 | 2019-03-01 | — | — | CN | disclosed |
| CN-109053742-A | New tricyclic compound | ABBVIE 公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108774237-A | New tricyclic compound | ABBVIE 公司 | 2018-11-09 | — | — | CN | disclosed |
| CN-108069976-A | A kind of nitrogenous macrocyclic compounds, its preparation method, pharmaceutical composition and application | 山东罗欣药业集团股份有限公司 | 2018-05-25 | — | — | CN | disclosed |
| CN-105130900-B | Antifungal pyrazoles | 纳幕尔杜邦公司 | 2018-05-22 | — | — | CN | disclosed |
| CN-107428706-A | As agricultural chemicals and the triazole derivative of plant growth regulator | 拜耳作物科学股份公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-102241664-B | Aralkyl diamine derivatives and use thereof as antidepressants | SHANGHAI INST PHARM INDUSTRY | 2014-11-12 | — | — | CN | disclosed |
| CN-103079406-A | Fungicidal pyrazoles | DU PONT | 2013-05-01 | — | — | CN | disclosed |
| US-7727654-B2 | Membrane of a sulfonated aromatic polymers having polyphenyl and polyphenylene ether units with fluorine and nitrile groups; higher proton conductivity over a wide temperature range, and exhibits superior hot water resistance, chemical stability, toughness and mechanical strength | HONDA MOTOR CO., LTD. (JP) | 2010-06-01 | — | — | US | disclosed |
| US-7727654-B2 | Membrane of a sulfonated aromatic polymers having polyphenyl and polyphenylene ether units with fluorine and nitrile groups; higher proton conductivity over a wide temperature range, and exhibits superior hot water resistance, chemical stability, toughness and mechanical strength | HONDA MOTOR CO., LTD. (JP) | 2010-06-01 | — | — | US | disclosed |
| US-7262265-B1 | High temperature thermoset compositions | SOLVAY ADVANCED POLYMERS, L.L.C. (US) | 2007-08-28 | — | — | US | disclosed |
| US-7262265-B1 | High temperature thermoset compositions | SOLVAY ADVANCED POLYMERS, L.L.C. (US) | 2007-08-28 | — | — | US | disclosed |
| CN-1045582-A | [5 (6) (benzisoxa -, benzisothia-or indazole-3 base)-1H-benzimidazolyl-2 radicals-yl] carbamate | JANSSEN PHARMACEUTICA NV (BE) | 1990-09-26 | — | — | CN | disclosed |