SCHEMBL13292773

SCHEMBL13292773

Nc1ccc(C(=O)Oc2ccc3ccc(OC(=O)c4ccc(N)cc4)cc3c2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 7/20 0.64
MEN1 O00255 3/20 0.64
MAPT P10636 2/20 0.64
TDP1 Q9NUW8 1/20 0.64
NR1H4 Q96RI1 1/20 0.57
F2 P00734 3/20 0.55
PRSS1 P07477 3/20 0.55
PRSS2 P07478 2/20 0.55
PRSS3 P35030 2/20 0.55
PKM P14618 1/20 0.55
HGFAC Q04756 2/20 0.51
ALDH1A1 P00352 2/20 0.51
TMPRSS2 O15393 1/20 0.51
MLNR O43193 1/20 0.51
C1R P00736 1/20 0.51
F10 P00742 1/20 0.51
PLG P00747 1/20 0.51
F12 P00748 1/20 0.51
LMNA P02545 1/20 0.51
ITGB3 P05106 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5710317 0.93 KMT2A (0.75) KMT2AMEN1MAPTTDP1NR1H4
SCHEMBL6052916 0.88 KMT2A (0.58) KMT2AMEN1MAPTTDP1NR1H4
SCHEMBL4132832 0.87 KMT2A (0.57) KMT2AMEN1MAPTTDP1NR1H4
SCHEMBL13292774 0.86 KMT2A (0.59) KMT2AMEN1MAPTTDP1NR1H4
SCHEMBL7342376 0.85 F12 (0.71) KMT2AMEN1MAPTTDP1NR1H4
SCHEMBL9788371 0.85 F2 (0.58) KMT2AMEN1MAPTTDP1NR1H4
SCHEMBL346698 0.85 PRSS1 (0.71) KMT2AMEN1NR1H4F2PRSS1
SCHEMBL107649 0.85 PRSS1 (0.71) KMT2AMEN1NR1H4F2PRSS1
SCHEMBL347429 0.85 PRSS1 (0.71) KMT2AMEN1NR1H4F2PRSS1
SCHEMBL11649516 0.83 KMT2A (0.60) KMT2AMEN1MAPTTDP1NR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130203895-A1 CURING AGENTS FOR EPOXY RESINS DESIGNER MOLECULES, INC. (US) 2013-08-08 US disclosed
US-20130203895-A1 CURING AGENTS FOR EPOXY RESINS DESIGNER MOLECULES, INC. (US) 2013-08-08 US disclosed
US-20130012620-A1 CURING AGENTS FOR EPOXY RESINS DESIGNER MOLECULES, INC. (US) 2013-01-10 US disclosed
US-20130012620-A1 CURING AGENTS FOR EPOXY RESINS DESIGNER MOLECULES, INC. (US) 2013-01-10 US disclosed
US-8288591-B2 Curing agents for epoxy resins DESIGNER MOLECULES, INC. (US) 2012-10-16 US disclosed
US-8288591-B2 Curing agents for epoxy resins DESIGNER MOLECULES, INC. (US) 2012-10-16 US disclosed
US-20100144977-A1 CURING AGENTS FOR EPOXY RESINS DESIGNER MOLECULES, INC. (US) 2010-06-10 US disclosed
US-20100144977-A1 CURING AGENTS FOR EPOXY RESINS DESIGNER MOLECULES, INC. (US) 2010-06-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130012620-A1 CURING AGENTS FOR EPOXY RESINS DOT1L, EHMT1, ASH1L KMT2A 271/4885MEN1 3864/4885MAPT 1749/4885
US-20100144977-A1 CURING AGENTS FOR EPOXY RESINS PTGER3, PTGER4, ELL KMT2A 669/4885MEN1 3568/4885MAPT 3745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.