Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.45 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15565006 | 0.84 | ALDH1A1 (0.58) | KDM4EALDH1A1HTTTSHRLTA4H | |
| SCHEMBL473301 | 0.83 | KDM4E (0.50) | KDM4EALDH1A1HTTTSHRLTA4H | |
| SCHEMBL8896665 | 0.83 | TSHR (0.55) | KDM4EALDH1A1HTTTSHRLTA4H | |
| SCHEMBL416807 | 0.81 | FDFT1 (0.51) | FFAR1FDFT1 | |
| SCHEMBL14319102 | 0.80 | LTA4H (0.61) | TSHRLTA4HFFAR1 | |
| SCHEMBL23312282 | 0.79 | ALDH1A1 (0.50) | KDM4EALDH1A1HTTTSHRLTA4H | |
| SCHEMBL358425 | 0.79 | LTA4H (0.67) | KDM4EALDH1A1HTTTSHRLTA4H | |
| SCHEMBL11090830 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1HTTTSHRLTA4H | |
| SCHEMBL8353925 | 0.79 | IDO1 (0.52) | KDM4EALDH1A1HTTTSHRLTA4H | |
| SCHEMBL1218850 | 0.79 | KDM4E (0.50) | KDM4EALDH1A1HTTTSHRLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507815-B2 | Succinoylamino lactams as inhibitors of a-β protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-03-24 | — | — | US | claimed |
| US-20080293692-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-11-27 | — | — | US | claimed |
| EP-0161827-A1 | Novel intermediate for the preparation of cyclopropane carboxylate esters and its preparation and use | INDIAN EXPLOSIVES LIMITED (IN) | 1985-11-21 | — | — | EP | claimed |
| CN-118076767-A | Method and formulation for producing an optical metal oxide layer | 默克专利有限公司 | 2024-05-24 | — | — | CN | disclosed |
| WO-2023057401-A1 | METHOD AND FORMULATION FOR PREPARING OPTICAL METAL OXIDE LAYERS | MERCK PATENT GMBH (DE) | 2023-04-13 | — | — | WO | disclosed |
| CN-101193908-B | Organic compounds | NOVARTIS AG | 2012-04-11 | — | — | CN | disclosed |
| US-20110281845-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-11-17 | — | — | US | disclosed |
| US-7989441-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-02 | — | — | US | disclosed |
| US-7507815-B2 | Succinoylamino lactams as inhibitors of a-β protein production | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2009-03-24 | — | — | US | disclosed |
| US-20090069294-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-03-12 | — | — | US | disclosed |
| US-20080293692-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-11-27 | — | — | US | disclosed |
| US-20020159947-A1 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | LANTHEUS MEDICAL IMAGING, INC. | 2002-10-31 | — | — | US | disclosed |
| US-6331408-B1 | CONTACTING A POTENTIAL INHIBITOR OF BETA-AMYLOID PRODUCTION AND TAGGED INHIBITOR OF BETA-AMYLOID PRODUCTION WITH AT MACROMOLECULE INVOLVED IN PROCESSING OF AMYLOID PRECURSOR PROTEIN; SEPARATING TAGGED INHIBITOR, DETERMINING | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2001-12-18 | — | — | US | disclosed |
| WO-2001087354-A2 | USE OF SMALL MOLECULE RADIOLIGANDS FOR DIAGNOSTIC IMAGING | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2001-11-22 | — | — | WO | disclosed |
| EP-1129355-A1 | USE OF RADIOLIGANDS TO SCREEN INHIBITORS OF AMYLOID-BETA PEPTIDE PRODUCTION | Du Pont Pharmaceuticals Company (US) | 2001-09-05 | — | — | EP | disclosed |
| CN-1311779-A | Succinoylamino lactams as inhibitors and as A beta protein production | DU PONT PHARM CO (US) | 2001-09-05 | — | — | CN | disclosed |
| EP-1102752-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A BETA PROTEIN PRODUCTION | Du Pont Pharmaceuticals Company (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000028331-A1 | USE OF RADIOLIGANDS TO SCREEN INHIBITORS OF AMYLOID-BETA PEPTIDE PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-05-18 | — | — | WO | disclosed |
| WO-2000007995-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-02-17 | — | — | WO | disclosed |
| EP-0161827-A1 | Novel intermediate for the preparation of cyclopropane carboxylate esters and its preparation and use | INDIAN EXPLOSIVES LIMITED (IN) | 1985-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069294-A1 | Organic Compounds | XIAP, BAX, MCL1 | KDM4E 2903/4885ALDH1A1 1673/4885HTT 2950/4885 |
| US-20110281845-A1 | ORGANIC COMPOUNDS | XIAP, BAX, MCL1 | KDM4E 2898/4885ALDH1A1 1672/4885HTT 2950/4885 |
| US-20020159947-A1 | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging | APP, BACE1, BACE2 | KDM4E 4802/4885ALDH1A1 4470/4885HTT 58/4885 |
| US-20080293692-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A-BETA PROTEIN PRODUCTION | BACE1, APH1A, APP | KDM4E 3215/4885ALDH1A1 2329/4885HTT 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.