SCHEMBL13301890

SCHEMBL13301890

N#CC(C#N)=C1C(=O)c2cc(Cl)ccc2-c2ccc(Cl)cc21

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 2/20 0.57
MAPT P10636 2/20 0.49
PKM P14618 2/20 0.49
ALDH1A1 P00352 1/20 0.49
GAA P10253 1/20 0.49
USP8 P40818 2/20 0.46
USP7 Q93009 2/20 0.46
USP47 Q96K76 1/20 0.46
HSP90AA1 P07900 1/20 0.45
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
PPOX P50336 1/20 0.39
METAP1 P53582 1/20 0.38
EGFR P00533 3/20 0.36
CES1 P23141 2/20 0.36
TGM2 P21980 1/20 0.36
ITGA1 P56199 1/20 0.35
HPRT1 P00492 1/20 0.35
TMPRSS4 Q9NRS4 1/20 0.33
F7 P08709 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13301896 0.92 S100A4 (0.59) S100A4MAPTPKMALDH1A1GAA
SCHEMBL13292069 0.80 S100A4 (0.49) S100A4MAPTPKMALDH1A1GAA
SCHEMBL12114273 0.79 ALDH1A1 (0.53) S100A4MAPTPKMALDH1A1GAA
SCHEMBL12113903 0.79 MAPT (0.49) MAPTPKMALDH1A1GAAUSP8
SCHEMBL21173223 0.79 S100A4 (0.43) S100A4MAPTPKMALDH1A1GAA
SCHEMBL21173228 0.79 USP8 (0.40) S100A4MAPTPKMALDH1A1GAA
SCHEMBL13302009 0.76 MAPT (0.45) MAPTPKMALDH1A1GAAMEN1
SCHEMBL11586897 0.75 HPRT1 (0.43) S100A4MAPTPKMALDH1A1GAA
SCHEMBL30345128 0.74 S100A4 (0.90) S100A4USP8USP7USP47HSP90AA1
SCHEMBL1133148 0.74 S100A4 (0.90) S100A4USP8USP7USP47HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7745083-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2010-06-29 US disclosed
US-20090297218-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2009-12-03 US disclosed
US-7592113-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2009-09-22 US disclosed
US-20080233499-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2008-09-25 US disclosed
US-7396622-B2 Having a charge generation layer containing a phenanthrene compound, a phenanthroline compound or an acenaphthene compound that has two oxo-, phenylimino- or dicyanovinylene groups that may be the same or different; charge-generating material is preferably hydroxygallium phthalocyanine. CANON KABUSHIKI KAISHA (JP) 2008-07-08 US disclosed