SCHEMBL13302012

SCHEMBL13302012

N#CC(C#N)=C1C(=O)c2cccnc2-c2ncc(C(F)(F)F)cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 1/20 0.42
NSD2 O96028 1/20 0.42
ABL1 P00519 1/20 0.42
PLCG1 P19174 1/20 0.42
CES1 P23141 1/20 0.42
PAX8 Q06710 1/20 0.42
RIN1 Q13671 1/20 0.42
GAA P10253 1/20 0.42
PTGS1 P23219 1/20 0.39
PTGS2 P35354 1/20 0.39
CTSL P07711 1/20 0.36
PTPRC P08575 1/20 0.36
CTSS P25774 1/20 0.36
PTPN13 Q12923 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
THRB P10828 1/20 0.36
BLM P54132 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
CDC25B P30305 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13302056 0.89 ALDH1A1 (0.34) GAAPTGS1PTGS2MEN1KMT2A
SCHEMBL13292081 0.85 TDP2 (0.38) TDP2NSD2ABL1PLCG1CES1
SCHEMBL13694206 0.82 KMT2A (0.39) GAAPTGS1PTGS2MEN1KMT2A
SCHEMBL13292079 0.82 TDP2 (0.59) TDP2NSD2ABL1PLCG1CES1
SCHEMBL13302011 0.82 TDP2 (0.58) TDP2NSD2ABL1PLCG1CES1
SCHEMBL13302054 0.81 TDP2 (0.45) TDP2NSD2ABL1PLCG1CES1
SCHEMBL16656342 0.77 TDP2 (0.40) TDP2NSD2ABL1PLCG1CES1
SCHEMBL13292083 0.74 TDP2 (0.42) TDP2NSD2ABL1PLCG1CES1
SCHEMBL13292090 0.73 PTGS2 (0.32) PTGS1PTGS2ALDH1A1KDM4E
SCHEMBL13302007 0.73 MAPT (0.42) TDP2NSD2GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7745083-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2010-06-29 US disclosed
US-20090297218-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2009-12-03 US disclosed
US-7592113-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2009-09-22 US disclosed
US-20080233499-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2008-09-25 US disclosed
US-7396622-B2 Having a charge generation layer containing a phenanthrene compound, a phenanthroline compound or an acenaphthene compound that has two oxo-, phenylimino- or dicyanovinylene groups that may be the same or different; charge-generating material is preferably hydroxygallium phthalocyanine. CANON KABUSHIKI KAISHA (JP) 2008-07-08 US disclosed