Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27753201 | 1.00 | SIGMAR1 (0.50) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| Bromide SCHEMBL1330634 | 1.00 | SIGMAR1 (0.50) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| Bromide SCHEMBL1331166 | 1.00 | SIGMAR1 (0.50) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| Bromide SCHEMBL1329464 | 0.98 | SIGMAR1 (0.49) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| Bromide SCHEMBL1329467 | 0.98 | SIGMAR1 (0.49) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| SCHEMBL23308021 | 0.98 | SIGMAR1 (0.51) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| SCHEMBL666712 | 0.98 | SIGMAR1 (0.51) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| SCHEMBL667263 | 0.98 | SIGMAR1 (0.51) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| SCHEMBL11258123 | 0.98 | SIGMAR1 (0.51) | SIGMAR1KCNH2CNR2ACKR3OPRK1 | |
| SCHEMBL667946 | 0.98 | SIGMAR1 (0.51) | SIGMAR1KCNH2CNR2ACKR3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8962662-B2 | Antimicrobial compositions and methods of use thereof | BYOCOAT ENTERPRISES, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| US-8586115-B2 | Antimicrobial solutions and process related thereto | BYOCOAT ENTERPRISES, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-20130137732-A1 | ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF | BYOCOAT ENTERPRISES, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| WO-2013074526-A2 | ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF | BYOCOAT ENTERPRISES, INC. (US) | 2013-05-23 | — | — | WO | disclosed |
| US-20120264758-A1 | ANTIMICROBIAL SOLUTIONS AND PROCESS RELATED THERETO | BYOCOAT ENTERPRISES, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20110281002-A1 | ANTIMICROBIAL SOLUTIONS AND PROCESS RELATED THERETO | BYOCOAT ENTERPRISES, INC. (PR) | 2011-11-17 | — | — | US | disclosed |
| US-20090192165-A1 | ANTIMICROBIAL SOLUTIONS AND PROCESS RELATED THERETO | BYOCOAT ENTERPRISES, INC. (PR) | 2009-07-30 | — | — | US | disclosed |
| EP-1931209-A1 | ANTIMICROBIAL SOLUTIONS AND PROCESS RELATED THERETO | Byocoat Enterprises, Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2008008362-A2 | COMPOSITIONS AND METHODS FOR REDUCING OR PREVENTING MICROORGANISM GROWTH OR SURVIVAL IN AQUEOUS ENVIRONMENTS | BYOCOAT ENTERPRISES, INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| WO-2007030104-A1 | ANTIMICROBIAL SOLUTIONS AND PROCESS RELATED THERETO | BYOCOAT ENTERPRISES, INC. (US) | 2007-03-15 | — | — | WO | disclosed |
| US-20060110506-A1 | Antimicrobial solutions and process related thereto | BYOCOAT ENTERPRISES, INC. | 2006-05-25 | — | — | US | disclosed |
| US-20050271781-A1 | Antimicrobial solutions and process related thereto | BYOCOAT ENTERPRISES, INC. | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137732-A1 | ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE THEREOF | KARS1, AAAS, AARS1 | SIGMAR1 793/4885KCNH2 187/4885CNR2 4092/4885 |
| US-20110281002-A1 | ANTIMICROBIAL SOLUTIONS AND PROCESS RELATED THERETO | DAO, AGPS, TH | SIGMAR1 509/4885KCNH2 1030/4885CNR2 4229/4885 |
| US-20090192165-A1 | ANTIMICROBIAL SOLUTIONS AND PROCESS RELATED THERETO | DAO, AGPS, DDC | SIGMAR1 955/4885KCNH2 1278/4885CNR2 4568/4885 |
| US-20120264758-A1 | ANTIMICROBIAL SOLUTIONS AND PROCESS RELATED THERETO | DAO, AGPS, DDC | SIGMAR1 955/4885KCNH2 1278/4885CNR2 4568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.