Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931066 | 0.89 | GSK3B (0.51) | KMT2AKDM4ETP53POLBGSK3B | |
| SCHEMBL14528759 | 0.85 | IKBKB (0.42) | KMT2AKDM4ETP53POLBGSK3B | |
| SCHEMBL13309241 | 0.80 | GSK3B (0.46) | KMT2AKDM4ETP53POLBGSK3B | |
| SCHEMBL13309052 | 0.80 | KDM4E (0.43) | KMT2AKDM4ETP53POLBGSK3B | |
| SCHEMBL13309461 | 0.79 | KDM4E (0.44) | KMT2AKDM4ETP53POLBGSK3B | |
| SCHEMBL13308747 | 0.78 | KDM4E (0.44) | KMT2AKDM4ETP53POLBGSK3B | |
| SCHEMBL13309116 | 0.78 | ALDH1A1 (0.49) | KMT2AKDM4ETP53POLBALDH1A1 | |
| SCHEMBL14528898 | 0.77 | KDM4E (0.41) | KMT2AKDM4ETP53POLBGSK3B | |
| SCHEMBL11931064 | 0.76 | GSK3B (0.55) | KDM4ETP53POLBGSK3BTSHR | |
| SCHEMBL13309125 | 0.75 | GSK3B (0.48) | KDM4ETP53POLBGSK3BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534712-B1 | PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2007-05-16 | — | — | EP | disclosed |