Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309967 | 0.94 | HSD11B1 (0.35) | EPHX2HSD11B1L3MBTL1EPHX1 | |
| SCHEMBL1502478 | 0.79 | HSD11B1 (0.34) | EPHX2HSD11B1L3MBTL1EPHX1 | |
| SCHEMBL1502358 | 0.77 | EPHX2 (0.35) | EPHX2HSD11B1L3MBTL1 | |
| SCHEMBL2023104 | 0.71 | HSD11B1 (0.49) | EPHX2HSD11B1L3MBTL1EPHX1 | |
| SCHEMBL1502489 | 0.64 | L3MBTL1 (0.40) | EPHX2HSD11B1L3MBTL1 | |
| SCHEMBL1403216 | 0.64 | L3MBTL1 (0.56) | EPHX2HSD11B1L3MBTL1 | |
| SCHEMBL1502382 | 0.64 | L3MBTL1 (0.41) | EPHX2HSD11B1L3MBTL1 | |
| SCHEMBL10272629 | 0.59 | EPHX2 (0.45) | EPHX2HSD11B1L3MBTL1 | |
| SCHEMBL14503294 | 0.59 | L3MBTL1 (0.52) | EPHX2HSD11B1L3MBTL1EPHX1 | |
| SCHEMBL10284318 | 0.58 | EPHX2 (0.41) | EPHX2HSD11B1L3MBTL1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797034-B1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-06-30 | — | — | EP | disclosed |