Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1502358 | 0.93 | EPHX2 (0.35) | HSD11B1EPHX2L3MBTL1 | |
| SCHEMBL1502382 | 0.82 | L3MBTL1 (0.41) | HSD11B1EPHX2L3MBTL1 | |
| SCHEMBL13309653 | 0.79 | EPHX2 (0.35) | HSD11B1EPHX2L3MBTL1EPHX1 | |
| SCHEMBL1502489 | 0.78 | L3MBTL1 (0.40) | HSD11B1EPHX2L3MBTL1 | |
| SCHEMBL4325169 | 0.76 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL13309967 | 0.75 | HSD11B1 (0.35) | HSD11B1EPHX2L3MBTL1EPHX1 | |
| SCHEMBL1502419 | 0.72 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL13309654 | 0.71 | CCR2 (0.33) | — | |
| SCHEMBL12759904 | 0.71 | HSD11B1 (0.36) | HSD11B1 | |
| SCHEMBL14503276 | 0.66 | EPHX2 (0.53) | HSD11B1EPHX2L3MBTL1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915252-B2 | Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915252-B2 | Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915252-B2 | Sulfonyl compounds as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 | MERCK SHARP & DOHME (US) | 2011-03-29 | — | — | US | disclosed |
| EP-1797034-B1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-06-30 | — | — | EP | disclosed |
| EP-1797034-B1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK SHARP & DOHME (US) | 2010-06-30 | — | — | EP | disclosed |
| EP-1797034-A4 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO INC (US) | 2009-07-15 | — | — | EP | disclosed |
| US-20080318930-A1 | Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2008-12-25 | — | — | US | disclosed |
| US-20080318930-A1 | Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2008-12-25 | — | — | US | disclosed |
| US-20080318930-A1 | Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | MERCK SHARP & DOHME LLC | 2008-12-25 | — | — | US | disclosed |
| EP-1797034-A1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | Merck & Co., Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006017542-A1 | SULFONYL COMPOUNDS AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO., INC. (US) | 2006-02-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318930-A1 | Sulfonyl Compound as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase-1 | HSD11B1, HSD17B1, HSD11B2 | HSD11B1 1/4885EPHX2 1817/4885L3MBTL1 3060/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.