Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.80 |
| ▸ | POLB | P06746 | 10/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.80 |
| ▸ | HPGD | P15428 | 6/20 | 0.80 |
| ▸ | GLA | P06280 | 4/20 | 0.80 |
| ▸ | GAA | P10253 | 3/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.80 |
| ▸ | ESR1 | P03372 | 1/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | RECQL | P46063 | 6/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.65 |
| ▸ | BLM | P54132 | 4/20 | 0.65 |
| ▸ | PKM | P14618 | 2/20 | 0.65 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4460070 | 0.89 | KDM4E (0.80) | KDM4EPOLBALDH1A1L3MBTL1TDP1 | |
| SCHEMBL29703130 | 0.89 | KDM4E (1.00) | KDM4EPOLBALDH1A1L3MBTL1TDP1 | |
| SCHEMBL116036 | 0.89 | KDM4E (1.00) | KDM4EPOLBALDH1A1L3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL4472928 | 0.87 | KDM4E (0.97) | KDM4EPOLBALDH1A1L3MBTL1TDP1 | |
| SCHEMBL28520534 | 0.86 | KDM4E (0.80) | KDM4EPOLBALDH1A1L3MBTL1TDP1 | |
| SCHEMBL17348467 | 0.83 | KDM4E (0.62) | KDM4EPOLBESR1MEN1KMT2A | |
| SCHEMBL3331112 | 0.82 | UBE2I (0.78) | KDM4EPOLBALDH1A1L3MBTL1TDP1 | |
| SCHEMBL29082945 | 0.82 | L3MBTL1 (0.79) | KDM4EPOLBALDH1A1L3MBTL1TDP1 | |
| SCHEMBL6209856 | 0.79 | KDM4E (0.76) | KDM4EPOLBESR1MEN1KMT2A | |
| SCHEMBL23722921 | 0.78 | CACNA1B (0.75) | KDM4EPOLBALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160255-A1 | SPIRO-CYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-24 | — | — | US | disclosed |
| US-20100160255-A1 | SPIRO-CYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160255-A1 | SPIRO-CYCLIC COMPOUND | ACACA, CPT1B, PC | KDM4E 1730/4885POLB 3928/4885ALDH1A1 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.