Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | IGFBP3 | P17936 | 4/20 | 0.39 |
| ▸ | IGFBP5 | P24593 | 2/20 | 0.39 |
| ▸ | IGFBP1 | P08833 | 1/20 | 0.39 |
| ▸ | IGFBP2 | P18065 | 1/20 | 0.39 |
| ▸ | IGFBP4 | P22692 | 1/20 | 0.39 |
| ▸ | IGFBP6 | P24592 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13271058 | 0.88 | KDM4E (0.47) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL10717399 | 0.82 | ALOX15 (0.41) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL31550535 | 0.82 | ALOX15 (0.41) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL31550536 | 0.82 | ALOX15 (0.41) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| Bromide SCHEMBL28861978 | 0.80 | ALOX15 (0.39) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL6080771 | 0.79 | GPR35 (0.46) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL6080581 | 0.79 | GPR35 (0.39) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL6081026 | 0.79 | GPR35 (0.39) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL6080551 | 0.76 | KDM4E (0.39) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL11380446 | 0.76 | ALOX15 (0.48) | ALOX15TSHRHIF1AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-06-24 | — | — | US | disclosed |
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-06-24 | — | — | US | disclosed |
| US-7692011-B2 | 8-hydroxy and 8-mercapto quinazolinones | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-04-06 | — | — | US | disclosed |
| US-7692011-B2 | 8-hydroxy and 8-mercapto quinazolinones | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | ACHE, PSEN1, PSEN2 | ALOX15 2133/4885TSHR 4642/4885HIF1A 3799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.