Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | SELL | P14151 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SELP | P16109 | 1/20 | 0.36 |
| ▸ | FUT4 | P22083 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31550536 | 0.98 | ALOX15 (0.41) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL10717399 | 0.98 | ALOX15 (0.41) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL31550535 | 0.98 | ALOX15 (0.41) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL13313445 | 0.80 | ALOX15 (0.52) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL8123552 | 0.74 | IGFBP3 (0.43) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL11380446 | 0.72 | ALOX15 (0.48) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL6080475 | 0.72 | KDM4E (0.44) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL6080287 | 0.72 | KDM4E (0.46) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL6080048 | 0.72 | GPR35 (0.45) | ALOX15TSHRHIF1AKDM4EKMT2A | |
| SCHEMBL13271058 | 0.70 | KDM4E (0.47) | ALOX15TSHRHIF1AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108383783-A | The synthetic method of 4,6- dihydroxy quinoline -5,8- diquinone -2- formic acid pharmaceutical intermediates | 成都卡迪夫科技有限公司 | 2018-08-10 | — | — | CN | disclosed |