Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.60 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.60 |
| ▸ | KIT | P10721 | 8/20 | 0.56 |
| ▸ | CSF1R | P07333 | 8/20 | 0.56 |
| ▸ | FLT1 | P17948 | 7/20 | 0.56 |
| ▸ | FLT3 | P36888 | 6/20 | 0.56 |
| ▸ | AURKA | O14965 | 6/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.56 |
| ▸ | LCK | P06239 | 5/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.56 |
| ▸ | STK3 | Q13188 | 4/20 | 0.56 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.56 |
| ▸ | FYN | P06241 | 4/20 | 0.56 |
| ▸ | LYN | P07948 | 4/20 | 0.56 |
| ▸ | BLK | P51451 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28804745 | 0.90 | FGFR1 (0.56) | KDRFGFR1DDR2KITCSF1R | |
| SCHEMBL28804742 | 0.90 | FGFR1 (0.56) | KDRFGFR1DDR2KITCSF1R | |
| SCHEMBL1331637 | 0.88 | KDR (0.64) | KDRFGFR1DDR2KITCSF1R | |
| SCHEMBL1332041 | 0.85 | KDR (0.69) | KDRFGFR1DDR2KITCSF1R | |
| SCHEMBL1331362 | 0.83 | FGFR1 (0.62) | KDRFGFR1DDR2KITCSF1R | |
| SCHEMBL1330486 | 0.81 | KDR (0.62) | KDRFGFR1DDR2KITCSF1R | |
| SCHEMBL1330072 | 0.80 | KDR (0.75) | KDRFGFR1KITCSF1RFLT1 | |
| SCHEMBL1331406 | 0.79 | FGFR1 (0.58) | KDRFGFR1DDR2KITCSF1R | |
| SCHEMBL1331714 | 0.79 | KDR (0.70) | KDRFGFR1KITCSF1RFLT1 | |
| SCHEMBL1330644 | 0.78 | FGFR1 (0.57) | KDRFGFR1DDR2KITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569301-A1 | INDAZOLE INHIBITORS OF KINASE | Abbvie Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| WO-2011143430-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | WO | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | KDR 11/4885FGFR1 227/4885DDR2 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.