Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.42 |
| ▸ | GRAMD1A | Q96CP6 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537016 | 0.88 | GCK (0.41) | GCKGRAMD1A | |
| SCHEMBL10764703 | 0.87 | GRAMD1A (0.43) | GCKGRAMD1APIK3CGALOX15 | |
| SCHEMBL3537071 | 0.81 | ALOX15 (0.44) | GRAMD1APIK3CGALOX15 | |
| SCHEMBL10825327 | 0.81 | GAA (0.42) | GRAMD1APIK3CGALOX15 | |
| SCHEMBL10825473 | 0.80 | ALDH1A1 (0.44) | GRAMD1APIK3CGALOX15 | |
| SCHEMBL3537610 | 0.80 | GRAMD1A (0.45) | GCKGRAMD1APIK3CGALOX15 | |
| SCHEMBL3534502 | 0.79 | GAA (0.43) | GRAMD1AALOX15 | |
| SCHEMBL10756470 | 0.79 | TSHR (0.42) | GRAMD1A | |
| SCHEMBL9385295 | 0.79 | GRM5 (0.51) | GCKGRAMD1APIK3CGALOX15 | |
| SCHEMBL10825442 | 0.79 | GAA (0.43) | GRAMD1APIK3CGALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |