Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13315955 | 0.79 | NCOA1 (0.40) | KMT2AKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13315970 | 0.76 | KDM4E (0.39) | KMT2AKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL28771116 | 0.76 | SMN1; SMN2 (0.40) | KMT2AALDH1A1GAASMN1; SMN2MEN1 | |
| SCHEMBL13315954 | 0.69 | ALDH1A1 (0.44) | KDM4EALDH1A1GAAMAPTPDE4A | |
| SCHEMBL4766186 | 0.69 | ADORA2B (0.43) | KMT2AKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL10961560 | 0.69 | KDM4E (0.48) | KDM4EALDH1A1GAASMN1; SMN2ATM | |
| SCHEMBL11170803 | 0.69 | KDM4E (0.48) | KDM4EALDH1A1GAASMN1; SMN2ATM | |
| SCHEMBL11170798 | 0.69 | KDM4E (0.46) | KDM4EALDH1A1GAASMN1; SMN2ATM | |
| Lithium Ion SCHEMBL11164273 | 0.69 | KDM4E (0.46) | KDM4EALDH1A1GAASMN1; SMN2ATM | |
| Potassium Ion SCHEMBL10961555 | 0.69 | KDM4E (0.46) | KDM4EALDH1A1GAASMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144764-A1 | PYRIMIDINEDIONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| WO-2008127591-A2 | PYRIMIDINEDIONE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144764-A1 | PYRIMIDINEDIONE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, TYMS, FPGS | KMT2A 2913/4885KDM4E 2442/4885ALDH1A1 99/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.