Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | GRK6 | P43250 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13315955 | 0.87 | NCOA1 (0.40) | KDM4EMAPK1NPSR1ALDH1A1MAPT | |
| SCHEMBL13315958 | 0.76 | KMT2A (0.40) | KDM4EALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL4769165 | 0.72 | PDE4A (0.39) | NPSR1CNR2ALDH1A1PDE4APDE4B | |
| SCHEMBL4772714 | 0.70 | ADORA2B (0.39) | KDM4EMAPK1CNR2ALDH1A1MAPT | |
| SCHEMBL4767722 | 0.68 | PDE4A (0.40) | NPSR1ALDH1A1TNFPDE4APDE4B | |
| SCHEMBL4772712 | 0.67 | ALDH1A1 (0.36) | KDM4ENPSR1ALDH1A1MAPTTNF | |
| SCHEMBL4767903 | 0.66 | RGS4 (0.46) | KDM4ENPSR1ALDH1A1MAPTTNF | |
| SCHEMBL4229116 | 0.65 | ADORA2A (0.40) | NPSR1ALDH1A1MAPTPDE4APDE4B | |
| SCHEMBL8176996 | 0.65 | RGS4 (0.36) | KDM4EMAPK1NPSR1CNR2ALDH1A1 | |
| SCHEMBL6239660 | 0.64 | RGS4 (0.50) | CNR2TNFPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144764-A1 | PYRIMIDINEDIONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| WO-2008127591-A2 | PYRIMIDINEDIONE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144764-A1 | PYRIMIDINEDIONE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, TYMS, FPGS | KDM4E 2442/4885MAPK1 2643/4885NPSR1 3108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.