Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNG2 | P59768 | 5/20 | 0.74 |
| ▸ | GNB1 | P62873 | 5/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | MET | P08581 | 3/20 | 0.51 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.50 |
| ▸ | HGF | P14210 | 2/20 | 0.49 |
| ▸ | P2RY4 | P51582 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.46 |
| ▸ | P2RY2 | P41231 | 5/20 | 0.46 |
| ▸ | P2RY6 | Q15077 | 3/20 | 0.46 |
| ▸ | ENTPD1 | P49961 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13320765 | 0.86 | GNG2 (0.61) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL2790949 | 0.85 | GNG2 (1.00) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL13718305 | 0.84 | GNG2 (0.65) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL13320767 | 0.81 | GNG2 (0.61) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11885192 | 0.81 | GNG2 (0.66) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL13320766 | 0.80 | GNG2 (0.62) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL10488725 | 0.77 | GNG2 (0.84) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL2778161 | 0.76 | GNG2 (1.00) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL29354288 | 0.76 | GNG2 (1.00) | GNG2GNB1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL3029899 | 0.75 | GNG2 (0.97) | GNG2GNB1CYP1A2CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8975259-B2 | Compositions and methods for inhibiting G protein signaling | UNIVERSITY OF ROCHESTER (US) | 2015-03-10 | — | — | US | disclosed |
| US-20100130505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | UNIVERSITY OF ROCHESTER (US) | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING | GNAI1, GNAI3, GNAI2 | GNG2 5/4885GNB1 4/4885CYP1A2 4839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.