Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13323884 | 0.82 | NPBWR1 (0.48) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPBWR1 | |
| SCHEMBL13324015 | 0.82 | ALOX5 (0.37) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPBWR1 | |
| SCHEMBL13324025 | 0.81 | NPBWR1 (0.43) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPBWR1 | |
| SCHEMBL13323912 | 0.75 | MAPT (0.44) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPBWR1 | |
| SCHEMBL10072551 | 0.75 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPC1 | |
| SCHEMBL13323954 | 0.74 | PPARG (0.39) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPBWR1 | |
| SCHEMBL9726416 | 0.69 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPBWR1 | |
| SCHEMBL13323993 | 0.68 | NPBWR1 (0.38) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPBWR1 | |
| SCHEMBL8220603 | 0.67 | ALDH1A1 (0.53) | ALDH1A1PTPN1LMNAKDM4EGAA | |
| SCHEMBL13324044 | 0.66 | PRKDC (0.38) | SMN1; SMN2ALDH1A1CYP1A2CYP2C19NPBWR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7718612-B2 | Pyridazinonyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2010-05-18 | — | — | US | disclosed |
| US-20090035272-A1 | Pyridazinonyl Macrocyclic Hepatitis C Serine Protease Inhibitors | ENANTA PHARMACEUTICALS, INC. | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090035272-A1 | Pyridazinonyl Macrocyclic Hepatitis C Serine Protease Inhibitors | PRSS1, SPINT2, TMPRSS4 | SMN1; SMN2 3333/4885ALDH1A1 975/4885CYP1A2 241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.