Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.48 |
| ▸ | RECQL | P46063 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | BLM | P54132 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | APEX1 | P27695 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29374017 | 1.00 | TDP1 (0.48) | TDP1RECQLKDM4EMAPTBLM | |
| SCHEMBL13176447 | 0.78 | TDP1 (0.48) | TDP1RECQLKDM4EMAPTBLM | |
| SCHEMBL2506281 | 0.77 | TSHR (0.61) | TDP1BLMKMT2AMEN1HPGD | |
| SCHEMBL30924863 | 0.77 | TSHR (0.61) | TDP1BLMKMT2AMEN1HPGD | |
| Formic Acid SCHEMBL29183960 | 0.77 | TDP1 (0.55) | TDP1RECQLKDM4EMAPTBLM | |
| SCHEMBL15973924 | 0.77 | KDM4E (0.43) | TDP1RECQLKDM4EMAPTBLM | |
| SCHEMBL15688141 | 0.77 | SHBG (0.44) | TDP1RECQLKDM4EMAPTBLM | |
| SCHEMBL20361608 | 0.77 | TDP1 (0.50) | TDP1RECQLKDM4EMAPTBLM | |
| SCHEMBL28165577 | 0.77 | TDP1 (0.50) | TDP1RECQLKDM4EMAPTBLM | |
| SCHEMBL7192542 | 0.77 | TDP1 (0.50) | TDP1RECQLKDM4EMAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116990405-A | Marker for predicting curative effect of ketamine on treating depression, screening method and application thereof | 广州医科大学附属脑科医院 | 2023-11-03 | — | — | CN | claimed |
| EP-2970124-B1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | UNIV LELAND STANFORD JUNIOR (US) | 2019-05-22 | — | — | EP | claimed |
| US-10227304-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-03-12 | — | — | US | claimed |
| CN-105358531-B | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | 利兰-斯坦福大学初级学院的董事会 | 2017-11-14 | — | — | CN | claimed |
| US-20170320828-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2017-11-09 | — | — | US | claimed |
| US-20170087280-A1 | SPATIOTEMPORALLY MULTICONTROLLABLE INTELIGENT DRUG-ELUTING STENT | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2017-03-30 | — | — | US | claimed |
| CN-106458910-A | Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer | 亚倍生技制药公司 | 2017-02-22 | — | — | CN | claimed |
| EP-3107899-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE 2 (ALDH2) BINDING POLYCYCLIC AMIDES AND THEIR USE FOR THE TREATMENT OF CANCER | Aldea Pharmaceuticals, Inc. (US) | 2016-12-28 | — | — | EP | claimed |
| CN-105358531-A | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | UNIV LELAND STANFORD JUNIOR | 2016-02-24 | — | — | CN | claimed |
| EP-2970124-A2 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | The Board of Trustees of the Leland Stanford Junior University (US) | 2016-01-20 | — | — | EP | claimed |
| EP-1511500-A4 | COMBINATION OF ANTI-MUSCARINIC AGENTS AND NON-GLUCOCORTICOID STEROIDS | EPIGENESIS PHARMACEUTICALS LLC (US) | 2009-04-29 | — | — | EP | claimed |
| JP-2006504666-A | — | — | 2006-02-09 | — | — | JP | claimed |
| EP-1511500-A2 | COMBINATION OF ANTI-MUSCARINIC AGENTS AND NON-GLUCOCORTICOID STEROIDS | Epigenesis Pharmaceuticals, Inc. (US) | 2005-03-09 | — | — | EP | claimed |
| WO-2004014293-A2 | COMBINATION OF ANTI-MUSCARINIC AGENTS AND NON-GLUCOCORTICOID STEROIDS | EPIGENESIS PHARMACEUTICALS, INC. (US) | 2004-02-19 | — | — | WO | claimed |
| US-20030216329-A1 | Composition, formulations & kit for treatment of respiratory & lung disease with dehydroepiandrosterone(s) steroid & an anti-muscarinic agent(s) | EPEGENESIS PHARMACEUTICALS, INC. | 2003-11-20 | — | — | US | claimed |
| US-6284750-B1 | DRUG, COSMETICS STEROID | ESTEE LAUDER INC. | 2001-09-04 | — | — | US | claimed |
| EP-0876391-B1 | NOVEL STEROID ESTERS USEFUL AGAINST SKIN DISORDERS | ESTEE LAUDER INC (US) | 2000-08-16 | — | — | EP | claimed |
| US-6025347-A | Steroid esters useful against skin disorders | ESTEE LAUDER INC. (US) | 2000-02-15 | — | — | US | claimed |
| US-5948418-A | MERCAPTANS | ESTEE LAUDER, INC. (US) | 1999-09-07 | — | — | US | claimed |
| US-5683705-A | Sulfur-based amides and bis-amides useful against skin disorders | ESTEE LAUDER, INC. (US) | 1997-11-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216329-A1 | Composition, formulations & kit for treatment of respiratory & lung disease with dehydroepiandrosterone(s) steroid & an anti-muscarinic agent(s) | KIT, NR5A1, CHRM5 | TDP1 3506/4885RECQL 521/4885KDM4E 1130/4885 |
| US-20170320828-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, DLD | TDP1 877/4885RECQL 392/4885KDM4E 2145/4885 |
| US-10227304-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | ALDH2, ALDH5A1, DLD | TDP1 877/4885RECQL 392/4885KDM4E 2145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.