SCHEMBL1332880

SCHEMBL1332880

CCCCCCc1ccccc1C(=O)Cl

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIPG Q9Y5X9 1/20 0.54
BID P55957 3/20 0.50
MCL1 Q07820 3/20 0.50
BCL2L1 Q07817 2/20 0.50
BAK1 Q16611 2/20 0.50
KAT8 Q9H7Z6 2/20 0.50
PPARA Q07869 2/20 0.50
PPARG P37231 1/20 0.50
EP300 Q09472 1/20 0.50
KAT2A Q92830 1/20 0.50
KAT2B Q92831 1/20 0.50
KAT5 Q92993 1/20 0.50
SAE1 Q9UBE0 1/20 0.50
THRA P10827 1/20 0.49
THRB P10828 1/20 0.49
CYSLTR2 Q9NS75 7/20 0.48
CYSLTR1 Q9Y271 7/20 0.48
TSHR P16473 1/20 0.47
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31602282 1.00 LIPG (0.54) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL963965 1.00 LIPG (0.54) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL9560320 1.00 LIPG (0.54) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL8093495 1.00 LIPG (0.54) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL8033375 0.98 LIPG (0.51) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL3181025 0.93 TSHR (0.44) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL12711080 0.91 F7 (0.56) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL7652499 0.86 LIPG (0.58) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL7651074 0.86 LIPG (0.58) LIPGBIDMCL1BCL2L1BAK1
SCHEMBL2970919 0.86 LIPG (0.58) LIPGBIDMCL1BCL2L1BAK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109574842-A Novel vegetable oil polyol and preparation method and application thereof 南京工业大学 2019-04-05 CN claimed
EP-2718755-B1 POLARIZING PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL INC (US) 2024-05-29 EP disclosed
EP-3367143-B1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL INC (US) 2023-01-11 EP disclosed
EP-1639058-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2020-10-21 EP disclosed
CN-105838349-B photochromic compounds 光学转变公司 2019-12-06 CN disclosed
EP-2357217-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-03-13 EP disclosed
EP-2357217-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2018-10-31 EP disclosed
EP-2360224-B1 Photochromic compounds TRANSITIONS OPTICAL INC (US) 2018-10-17 EP disclosed
EP-3367143-A1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME Transitions Optical, Inc. (US) 2018-08-29 EP disclosed
EP-1642160-B1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL INC (US) 2018-04-11 EP disclosed
US-20050080113-A1 Medicinal compositions TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-04-14 US disclosed
WO-2005005570-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2005-01-20 WO disclosed
US-20050012998-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2005-01-20 US disclosed
WO-2005006035-A1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL, INC. (US) 2005-01-20 WO disclosed
US-20050004361-A1 Thermally reversible; absorption ratio greater than 2.3 TRANSITIONS OPTICAL LIMITED (IE) 2005-01-06 US disclosed
EP-0708077-B1 Diamino compounds and methods for preparing them CHISSO CORP (JP) 2000-12-27 EP disclosed
US-5663440-A Diamino compounds and methods for preparing them CHISSO CORPORATION (JP) 1997-09-02 US disclosed
EP-0708077-A1 Diamino compounds and methods for preparing them CHISSO CORPORATION (JP) 1996-04-24 EP disclosed
EP-0385692-A2 Optcally active compounds SANYO CHEMICAL INDUSTRIES LTD. (JP) 1990-09-05 EP disclosed
US-4099856-A Nematic liquid crystalline substances VEB WERK FUR FERNSEHELEKTRONIK (DD) 1978-07-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050080113-A1 Medicinal compositions TNF, TRAF6, MMP8 LIPG 1560/4885BID 2231/4885MCL1 903/4885
US-20050004361-A1 Thermally reversible; absorption ratio greater than 2.3 CCND1, CCND3, CCND2 LIPG 4215/4885BID 4184/4885MCL1 2296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.