SCHEMBL1332977

SCHEMBL1332977

O=C(OCCOCCOCCOCC1CO1)c1c2c(c3ccccc3c1-c1ccccc1)OC(c1ccccc1)(c1ccccc1)C=C2

nearest known ligand 0.38

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 6/20 0.34
MEN1 O00255 1/20 0.31
LMNA P02545 1/20 0.31
KMT2A Q03164 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
TP53 P04637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7597572 0.88 TP53 (0.41) MEN1LMNAKMT2ASMN1; SMN2TP53
SCHEMBL7596981 0.88 TP53 (0.41) MEN1LMNAKMT2ASMN1; SMN2TP53
SCHEMBL23800877 0.87 LMNA (0.34) MEN1LMNAKMT2ASMN1; SMN2TP53
SCHEMBL30175143 0.87 LMNA (0.34) MEN1LMNAKMT2ASMN1; SMN2TP53
SCHEMBL1332454 0.81 MEN1 (0.32) MEN1LMNAKMT2ASMN1; SMN2
SCHEMBL1334130 0.80 L3MBTL1 (0.35) MEN1LMNAKMT2ASMN1; SMN2TP53
SCHEMBL1332545 0.80 L3MBTL1 (0.35) MEN1LMNAKMT2ASMN1; SMN2TP53
SCHEMBL1332475 0.80 L3MBTL1 (0.35) MEN1LMNAKMT2ASMN1; SMN2TP53
SCHEMBL29565409 0.80 L3MBTL1 (0.35) MEN1LMNAKMT2ASMN1; SMN2TP53
SCHEMBL29565416 0.80 L3MBTL1 (0.35) MEN1LMNAKMT2ASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1112263-B1 POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2005-06-08 EP claimed
US-6113814-A PHOTOCHROMIC; END-CAPPED WITH A POLYMERIZABLE GROUP. TRANSITIONS OPTICAL, INC. (US) 2000-09-05 US claimed
EP-2718755-B1 POLARIZING PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL INC (US) 2024-05-29 EP disclosed
CN-103635837-A Polarizing photochromic articles TRANSITIONS OPTICAL INC 2014-03-12 CN disclosed
US-8582192-B2 Polarizing photochromic articles TRANSITIONS OPTICAL, INC. (US) 2013-11-12 US disclosed
US-20110279883-A1 POLARIZING PHOTOCHROMIC ARTICLES TRANSITIONS OPTICAL, INC. (US) 2011-11-17 US disclosed
EP-1112263-B1 POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2005-06-08 EP disclosed
US-6113814-A PHOTOCHROMIC; END-CAPPED WITH A POLYMERIZABLE GROUP. TRANSITIONS OPTICAL, INC. (US) 2000-09-05 US disclosed