Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 8/20 | 0.49 |
| ▸ | CTSS | P25774 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15627772 | 0.89 | CTSK (0.47) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL25469335 | 0.88 | MEN1 (0.49) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL29734569 | 0.88 | CTSK (0.50) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL23728734 | 0.88 | CTSK (0.50) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL23728735 | 0.88 | CTSK (0.50) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL25696029 | 0.88 | CTSK (0.50) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL2367531 | 0.87 | MEN1 (0.55) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL7364210 | 0.87 | MEN1 (0.55) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL1486276 | 0.87 | MEN1 (0.55) | CTSKCTSSMEN1GAAKMT2A | |
| SCHEMBL12267031 | 0.87 | MEN1 (0.48) | CTSKCTSSMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100124543-A1 | SULPHONAMIDE DERIVATIVES AS PRODRUGS OF ASPARTYL PROTEASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-20 | — | — | US | disclosed |
| US-7592368-B2 | Sulphonamide derivatives as prodrugs of aspartyl protease inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100124543-A1 | SULPHONAMIDE DERIVATIVES AS PRODRUGS OF ASPARTYL PROTEASE INHIBITORS | PRSS1, TMPRSS15, SI | CTSK 136/4885CTSS 30/4885MEN1 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.